Cell atlas - DDX28 - The Human Protein Atlas

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DDX28

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS MOUSE CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Mitochondria
	Nucleoli

Human cell
	Cytosol
	Mitochondria
	Nucleoli

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GENERAL INFORMATION
Gene name	DDX28
Gene description	DEAD (Asp-Glu-Ala-Asp) box polypeptide 28
Protein class	Enzymes Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the cytosol & mitochondria. In addition localized to the nucleoli.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Mitochondria (supported), Cytosol (supported)
Additional location	In addition localized to the Nucleoli (supported)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Supported based on 2 antibodies. HPA041911 , HPA053585
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ASSAYS

RNA expression

Human cells

Mouse cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the cytosol & mitochondria. In addition localized to the nucleoli.

Main location

Mitochondria (supported), Cytosol (supported)

Additional location

Nucleoli (supported)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location	Single-cell variation
HPA041911	A-431	Nucleoli
HPA041911	A-431	Cytosol
HPA041911	U-2 OS	Mitochondria
HPA041911	U-251 MG	Nucleus
		Nucleoli	Intensity
		Cytosol
HPA053585	A-431	Cytosol
HPA053585	U-2 OS	Mitochondria
HPA053585	U-251 MG	Cytosol

MOUSE CELLS

Main location

Not available

Mouse gene

ENSMUSG00000045538 (version 83)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location
	HPA053585	NIH 3T3	No staining

GENE INFORMATION
Gene name	DDX28 (HGNC Symbol)
Synonyms	FLJ11282, MDDX28
Description	DEAD (Asp-Glu-Ala-Asp) box polypeptide 28 (HGNC Symbol)
Entrez gene summary	DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of the DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene is intronless. It encodes an RNA-dependent ATPase. The encoded protein is localized in the mitochondria and the nucleus, and can be transported between the mitochondria and the nucleus. [provided by RefSeq, Jul 2008]
Chromosome	16
Cytoband	q22.1
Chromosome location (bp)	68021274 - 68023442
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000182810 (version 83.38)
Entrez gene	55794
UniProt	Q9NUL7 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NUL7
Antibodypedia	DDX28 antibodies

PROTEIN BROWSER

DDX28-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DDX28-001 ENSP00000332340 ENST00000332395	Q9NUL7 [Direct mapping] Probable ATP-dependent RNA helicase DDX28 Show all	Enzymes ENZYME proteins Hydrolases Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0004004 [ATP-dependent RNA helicase activity] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0010501 [RNA secondary structure unwinding] GO:0019843 [rRNA binding] GO:0035770 [ribonucleoprotein granule] GO:0042645 [mitochondrial nucleoid] GO:0044822 [poly(A) RNA binding] GO:1902775 [mitochondrial large ribosomal subunit assembly] Show all	540 aa 59.6 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.