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RBM10

GENERAL INFORMATION

Gene name

 RBM10

Gene description

 RNA binding motif protein 10

Protein class

 Cancer-related genes
Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA034972
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (favourable) and cervical cancer (favourable).
Pancreatic cancer p<0.001
Cervical cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA034972

GENE INFORMATION

Gene name

 RBM10 (HGNC Symbol)

Synonyms

 DXS8237E, GPATC9, GPATCH9, KIAA0122, ZRANB5

Description

 RNA binding motif protein 10 (HGNC Symbol)

Entrez gene summary

 This gene encodes a nuclear protein that belongs to a family proteins that contain an RNA-binding motif. The encoded protein associates with hnRNP proteins and may be involved in regulating alternative splicing. Defects in this gene are the cause of the X-linked recessive disorder, TARP syndrome. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Mar 2011]

Chromosome

 X

Cytoband

 p11.3

Chromosome location (bp)

 47144869 - 47186813

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000182872 (version 83.38)

Entrez gene

 8241

UniProt

 P98175 (UniProt - Evidence at protein level)

neXtProt

 NX_P98175

Antibodypedia

 RBM10 antibodies

PROTEIN BROWSER
RBM10-001
RBM10-005
RBM10-006
RBM10-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RBM10-001
ENSP00000329659
ENST00000345781
P98175 [Direct mapping]
RNA-binding protein 10
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Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006397 [mRNA processing]
GO:0008150 [biological_process]
GO:0008270 [zinc ion binding]
GO:0008380 [RNA splicing]
GO:0032403 [protein complex binding]
GO:0042802 [identical protein binding]
GO:0044822 [poly(A) RNA binding]
GO:0046872 [metal ion binding]
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 853 aa
94.5 kDa 		No 0
RBM10-005
ENSP00000366829
ENST00000377604
P98175 [Direct mapping]
RNA-binding protein 10
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006397 [mRNA processing]
GO:0008150 [biological_process]
GO:0008270 [zinc ion binding]
GO:0008380 [RNA splicing]
GO:0032403 [protein complex binding]
GO:0042802 [identical protein binding]
GO:0044822 [poly(A) RNA binding]
GO:0046872 [metal ion binding]
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 930 aa
103.5 kDa 		No 0
RBM10-006
ENSP00000486115
ENST00000628161
P98175 [Direct mapping]
RNA-binding protein 10
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006397 [mRNA processing]
GO:0008150 [biological_process]
GO:0008270 [zinc ion binding]
GO:0008380 [RNA splicing]
GO:0032403 [protein complex binding]
GO:0042802 [identical protein binding]
GO:0044822 [poly(A) RNA binding]
GO:0046872 [metal ion binding]
Show all
 852 aa
94.4 kDa 		No 0
RBM10-201
ENSP00000328848
ENST00000329236
A0A0A0MR66 [Direct mapping]
RNA binding motif protein 10, isoform CRA_d; RNA-binding protein 10
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Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
GO:0008270 [zinc ion binding]
GO:0008285 [negative regulation of cell proliferation]
GO:0034391 [regulation of smooth muscle cell apoptotic process]
GO:0034393 [positive regulation of smooth muscle cell apoptotic process]
GO:0046872 [metal ion binding]
GO:0048025 [negative regulation of mRNA splicing, via spliceosome]
GO:0070935 [3'-UTR-mediated mRNA stabilization]
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 995 aa
110.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.