Expression of ADGRG3 in cancer - Summary - The Human Protein Atlas

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ADGRG3

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ADGRG3
Gene description	Adhesion G protein-coupled receptor G3
Protein class	G-protein coupled receptors Plasma proteins Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (NB-4, SK-MEL-30)
HPA (normal tissue):	Group enriched (appendix, bone marrow)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification. Antibody staining not consistent with RNA expression data.
Reliability score	Uncertain based on 1 antibody. HPA040469
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA040469

GENE INFORMATION
Gene name	ADGRG3 (HGNC Symbol)
Synonyms	GPR97, Pb99, PGR26
Description	Adhesion G protein-coupled receptor G3 (HGNC Symbol)
Entrez gene summary
Chromosome	16
Cytoband	q21
Chromosome location (bp)	57668187 - 57689378
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000182885 (version 83.38)
Entrez gene	222487
UniProt	Q86Y34 (UniProt - Evidence at protein level)
neXtProt	NX_Q86Y34
Antibodypedia	ADGRG3 antibodies

PROTEIN BROWSER

ADGRG3-001	ADGRG3-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ADGRG3-001 ENSP00000332900 ENST00000333493	Q86Y34 [Direct mapping] Adhesion G protein-coupled receptor G3 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Family 2 (B) receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0005886 [plasma membrane] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030183 [B cell differentiation] GO:0030334 [regulation of cell migration] GO:0032792 [negative regulation of CREB transcription factor activity] GO:1901223 [negative regulation of NIK/NF-kappaB signaling] Show all	549 aa 60.9 kDa	Yes	7
ADGRG3-003 ENSP00000404803 ENST00000450388	F8W8F7 [Direct mapping] Protein ADGRG3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	429 aa 47.4 kDa	No	7

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.