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CEP63

GENERAL INFORMATION

Gene name

 CEP63

Gene description

 Centrosomal protein 63kDa

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 12
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA058154
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA058154

GENE INFORMATION

Gene name

 CEP63 (HGNC Symbol)

Synonyms

 FLJ13386

Description

 Centrosomal protein 63kDa (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein with six coiled-coil domains. The protein is localized to the centrosome, a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells. Several alternatively spliced transcript variants have been found, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

Chromosome

 3

Cytoband

 q22.2

Chromosome location (bp)

 134485743 - 134575017

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000182923 (version 83.38)

Entrez gene

 80254

UniProt

 Q96MT8 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96MT8

Antibodypedia

 CEP63 antibodies

PROTEIN BROWSER
«
CEP63-001
CEP63-002
CEP63-003
CEP63-004
CEP63-009
CEP63-010
CEP63-011
CEP63-012
CEP63-013
CEP63-014
CEP63-201
CEP63-202
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CEP63-001
ENSP00000426129
ENST00000513612
Q96MT8 [Direct mapping]
Centrosomal protein of 63 kDa
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000077 [DNA damage checkpoint]
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0000922 [spindle pole]
GO:0005515 [protein binding]
GO:0005813 [centrosome]
GO:0005814 [centriole]
GO:0005829 [cytosol]
GO:0006996 [organelle organization]
GO:0007067 [mitotic nuclear division]
GO:0007099 [centriole replication]
GO:0042770 [signal transduction in response to DNA damage]
GO:0051225 [spindle assembly]
GO:0051301 [cell division]
GO:0098535 [de novo centriole assembly]
Show all
 703 aa
81.3 kDa 		No 0
CEP63-002
ENSP00000372716
ENST00000383229
Q96MT8 [Direct mapping]
Centrosomal protein of 63 kDa
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000077 [DNA damage checkpoint]
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0000922 [spindle pole]
GO:0005515 [protein binding]
GO:0005813 [centrosome]
GO:0005814 [centriole]
GO:0005829 [cytosol]
GO:0006996 [organelle organization]
GO:0007067 [mitotic nuclear division]
GO:0007099 [centriole replication]
GO:0042770 [signal transduction in response to DNA damage]
GO:0051225 [spindle assembly]
GO:0051301 [cell division]
GO:0098535 [de novo centriole assembly]
Show all
 541 aa
63 kDa 		No 0
CEP63-003
ENSP00000328382
ENST00000332047
Q96MT8 [Direct mapping]
Centrosomal protein of 63 kDa
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000077 [DNA damage checkpoint]
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0000922 [spindle pole]
GO:0005515 [protein binding]
GO:0005813 [centrosome]
GO:0005814 [centriole]
GO:0005829 [cytosol]
GO:0006996 [organelle organization]
GO:0007067 [mitotic nuclear division]
GO:0007099 [centriole replication]
GO:0042770 [signal transduction in response to DNA damage]
GO:0051225 [spindle assembly]
GO:0051301 [cell division]
GO:0098535 [de novo centriole assembly]
Show all
 495 aa
57.9 kDa 		No 0
CEP63-004
ENSP00000346432
ENST00000354446
Q96MT8 [Direct mapping]
Centrosomal protein of 63 kDa
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000077 [DNA damage checkpoint]
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0000922 [spindle pole]
GO:0005515 [protein binding]
GO:0005813 [centrosome]
GO:0005814 [centriole]
GO:0005829 [cytosol]
GO:0006996 [organelle organization]
GO:0007067 [mitotic nuclear division]
GO:0007099 [centriole replication]
GO:0042770 [signal transduction in response to DNA damage]
GO:0051225 [spindle assembly]
GO:0051301 [cell division]
GO:0098535 [de novo centriole assembly]
Show all
 475 aa
55.6 kDa 		No 0
CEP63-009
ENSP00000424626
ENST00000511574
D6RAY6 [Direct mapping]
Centrosomal protein of 63 kDa
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 162 aa
19.4 kDa 		No 0
CEP63-010
ENSP00000423225
ENST00000512894
D6R9Q4 [Direct mapping]
Centrosomal protein of 63 kDa
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 63 aa
7.2 kDa 		No 0
CEP63-011
ENSP00000426866
ENST00000504929
H0YAE6 [Direct mapping]
Centrosomal protein of 63 kDa
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 245 aa
28.3 kDa 		No 0
CEP63-012
ENSP00000427526
ENST00000514678
H0YAL1 [Direct mapping]
Centrosomal protein of 63 kDa
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 194 aa
22.3 kDa 		No 0
CEP63-013
ENSP00000422685
ENST00000508778
H0Y900 [Direct mapping]
Centrosomal protein of 63 kDa
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 155 aa
18.7 kDa 		No 0
CEP63-014
ENSP00000475903
ENST00000606977
Q96MT8 [Direct mapping]
Centrosomal protein of 63 kDa
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000077 [DNA damage checkpoint]
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0000922 [spindle pole]
GO:0005515 [protein binding]
GO:0005813 [centrosome]
GO:0005814 [centriole]
GO:0005829 [cytosol]
GO:0006996 [organelle organization]
GO:0007067 [mitotic nuclear division]
GO:0007099 [centriole replication]
GO:0042770 [signal transduction in response to DNA damage]
GO:0051225 [spindle assembly]
GO:0051301 [cell division]
GO:0098535 [de novo centriole assembly]
Show all
 703 aa
81.3 kDa 		No 0
CEP63-201
ENSP00000336524
ENST00000337090
Q96MT8 [Direct mapping]
Centrosomal protein of 63 kDa
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000077 [DNA damage checkpoint]
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0000922 [spindle pole]
GO:0005515 [protein binding]
GO:0005813 [centrosome]
GO:0005814 [centriole]
GO:0005829 [cytosol]
GO:0006996 [organelle organization]
GO:0007067 [mitotic nuclear division]
GO:0007099 [centriole replication]
GO:0042770 [signal transduction in response to DNA damage]
GO:0051225 [spindle assembly]
GO:0051301 [cell division]
GO:0098535 [de novo centriole assembly]
Show all
 703 aa
81.3 kDa 		No 0
CEP63-202
ENSP00000482219
ENST00000620544
Q96MT8 [Direct mapping]
Centrosomal protein of 63 kDa
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000077 [DNA damage checkpoint]
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0000922 [spindle pole]
GO:0005515 [protein binding]
GO:0005813 [centrosome]
GO:0005814 [centriole]
GO:0005829 [cytosol]
GO:0006996 [organelle organization]
GO:0007067 [mitotic nuclear division]
GO:0007099 [centriole replication]
GO:0042770 [signal transduction in response to DNA damage]
GO:0051225 [spindle assembly]
GO:0051301 [cell division]
GO:0098535 [de novo centriole assembly]
Show all
 475 aa
55.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.