Cell atlas - GJC1 - The Human Protein Atlas

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GJC1

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cell Junctions
	Cytosol
	Nucleoli

Human cell
	Cytosol
	Nucleoli
	Plasma Membrane

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GENERAL INFORMATION
Gene name	GJC1
Gene description	Gap junction protein, gamma 1, 45kDa
Protein class	Predicted intracellular proteins Predicted membrane proteins Transporters
Predicted localization	Intracellular,Membrane
Number of transcripts	9
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoli & cytosol. In addition localized to the cell junctions.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoli (uncertain), Cytosol (uncertain)
Additional location	In addition localized to the Cell Junctions (supported)

DATA RELIABILITY
Reliability score	Uncertain based on 1 antibody. HPA071788
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoli & cytosol. In addition localized to the cell junctions.

Main location

Nucleoli (uncertain), Cytosol (uncertain)

Additional location

Cell Junctions (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA071788	A-431	Nucleoli
	HPA071788	A-431	Cell Junctions
	HPA071788	RH-30	Nucleoli
	HPA071788	RH-30	Cytosol
	HPA071788	U-2 OS	Nucleoli

GENE INFORMATION
Gene name	GJC1 (HGNC Symbol)
Synonyms	CX45, GJA7
Description	Gap junction protein, gamma 1, 45kDa (HGNC Symbol)
Entrez gene summary	This gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. Alternatively spliced transcript variants encoding the same isoform have been described. [provided by RefSeq, Jul 2008]
Chromosome	17
Cytoband	q21.31
Chromosome location (bp)	44798448 - 44830816
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000182963 (version 83.38)
Entrez gene	10052
UniProt	P36383 (UniProt - Evidence at protein level)
neXtProt	NX_P36383
Antibodypedia	GJC1 antibodies

PROTEIN BROWSER

GJC1-001	GJC1-002	GJC1-003	GJC1-004	GJC1-005	GJC1-007	GJC1-008	GJC1-009	GJC1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GJC1-001 ENSP00000466339 ENST00000590758	P36383 [Direct mapping] Gap junction gamma-1 protein Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005789 [endoplasmic reticulum membrane] GO:0005886 [plasma membrane] GO:0005921 [gap junction] GO:0005922 [connexon complex] GO:0006810 [transport] GO:0006936 [muscle contraction] GO:0007043 [cell-cell junction assembly] GO:0007154 [cell communication] GO:0007268 [synaptic transmission] GO:0014704 [intercalated disc] GO:0016021 [integral component of membrane] GO:0016264 [gap junction assembly] GO:0061024 [membrane organization] GO:0086014 [atrial cardiac muscle cell action potential] Show all	396 aa 45.5 kDa	No	4
GJC1-002 ENSP00000467201 ENST00000592524	P36383 [Direct mapping] Gap junction gamma-1 protein Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005789 [endoplasmic reticulum membrane] GO:0005886 [plasma membrane] GO:0005921 [gap junction] GO:0005922 [connexon complex] GO:0006810 [transport] GO:0006936 [muscle contraction] GO:0007043 [cell-cell junction assembly] GO:0007154 [cell communication] GO:0007268 [synaptic transmission] GO:0014704 [intercalated disc] GO:0016021 [integral component of membrane] GO:0016264 [gap junction assembly] GO:0061024 [membrane organization] GO:0086014 [atrial cardiac muscle cell action potential] Show all	396 aa 45.5 kDa	No	4
GJC1-003 ENSP00000333193 ENST00000330514	P36383 [Direct mapping] Gap junction gamma-1 protein Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005789 [endoplasmic reticulum membrane] GO:0005886 [plasma membrane] GO:0005921 [gap junction] GO:0005922 [connexon complex] GO:0006810 [transport] GO:0006936 [muscle contraction] GO:0007043 [cell-cell junction assembly] GO:0007154 [cell communication] GO:0007268 [synaptic transmission] GO:0014704 [intercalated disc] GO:0016021 [integral component of membrane] GO:0016264 [gap junction assembly] GO:0061024 [membrane organization] GO:0086014 [atrial cardiac muscle cell action potential] Show all	396 aa 45.5 kDa	No	4
GJC1-004 ENSP00000466392 ENST00000591424	K7EM78 [Direct mapping] Gap junction protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005922 [connexon complex] GO:0007154 [cell communication] GO:0016021 [integral component of membrane] Show all	103 aa 11.9 kDa	No	2
GJC1-005 ENSP00000467090 ENST00000586267	K7ENT9 [Direct mapping] Gap junction protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005922 [connexon complex] GO:0007154 [cell communication] GO:0016021 [integral component of membrane] Show all	70 aa 8 kDa	No	1
GJC1-007 ENSP00000467626 ENST00000587239	K7EQ14 [Direct mapping] Gap junction protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005922 [connexon complex] GO:0007154 [cell communication] GO:0016021 [integral component of membrane] Show all	72 aa 8.2 kDa	No	1
GJC1-008 ENSP00000468258 ENST00000586347	K7ERH3 [Direct mapping] Gap junction gamma-1 protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005922 [connexon complex] GO:0007154 [cell communication] Show all	113 aa 12.3 kDa	No	0
GJC1-009 ENSP00000468716 ENST00000587113	Q5H9P2 [Direct mapping] Gap junction protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005922 [connexon complex] GO:0007154 [cell communication] GO:0016021 [integral component of membrane] Show all	260 aa 29.7 kDa	No	2
GJC1-201 ENSP00000411528 ENST00000426548	P36383 [Direct mapping] Gap junction gamma-1 protein Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0001570 [vasculogenesis] GO:0005216 [ion channel activity] GO:0005243 [gap junction channel activity] GO:0005515 [protein binding] GO:0005789 [endoplasmic reticulum membrane] GO:0005886 [plasma membrane] GO:0005921 [gap junction] GO:0005922 [connexon complex] GO:0006810 [transport] GO:0006936 [muscle contraction] GO:0007043 [cell-cell junction assembly] GO:0007154 [cell communication] GO:0007267 [cell-cell signaling] GO:0007268 [synaptic transmission] GO:0007507 [heart development] GO:0007601 [visual perception] GO:0014704 [intercalated disc] GO:0016021 [integral component of membrane] GO:0016264 [gap junction assembly] GO:0034220 [ion transmembrane transport] GO:0048468 [cell development] GO:0048738 [cardiac muscle tissue development] GO:0061024 [membrane organization] GO:0086014 [atrial cardiac muscle cell action potential] Show all	396 aa 45.5 kDa	No	4

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.