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SOX1

GENERAL INFORMATION

Gene name

 SOX1

Gene description

 SRY (sex determining region Y)-box 1

Protein class

 Cancer-related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Group enriched (colorectal cancer, glioma, melanoma)
HPA (cell line):Group enriched (AF22, SCLC-21H)
HPA (normal tissue):Group enriched (cerebral cortex, testis)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Group enriched (colorectal cancer, glioma, melanoma)

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 SOX1

Synonyms

Description

 SRY (sex determining region Y)-box 1 (HGNC Symbol)

Entrez gene summary

 This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. In mice, a similar protein regulates the gamma-crystallin genes and is essential for lens development. [provided by RefSeq, Jul 2008]

Chromosome

 13

Cytoband

 q34

Chromosome location (bp)

 112067647 - 112070488

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000182968 (version 83.38)

Entrez gene

 6656

UniProt

 O00570 (UniProt - Evidence at protein level)

neXtProt

 NX_O00570

Antibodypedia

 SOX1 antibodies

PROTEIN BROWSER
SOX1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SOX1-001
ENSP00000330218
ENST00000330949
O00570 [Direct mapping]
Transcription factor SOX-1
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   TMHMM predicted membrane proteins
Predicted intracellular proteins
Transcription factors
   Other all-alpha-helical DNA-binding domains
Cancer-related genes
   Candidate cancer biomarkers
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GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001046 [core promoter sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001764 [neuron migration]
GO:0002089 [lens morphogenesis in camera-type eye]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006325 [chromatin organization]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0021521 [ventral spinal cord interneuron specification]
GO:0021879 [forebrain neuron differentiation]
GO:0021884 [forebrain neuron development]
GO:0030900 [forebrain development]
GO:0043565 [sequence-specific DNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
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 391 aa
39 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.