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CNOT10

GENERAL INFORMATION

Gene name

 CNOT10

Gene description

 CCR4-NOT transcription complex, subunit 10

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Granular cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA035614
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA035614

GENE INFORMATION

Gene name

 CNOT10 (HGNC Symbol)

Synonyms

 FLJ12890, FLJ13165

Description

 CCR4-NOT transcription complex, subunit 10 (HGNC Symbol)

Entrez gene summary

Chromosome

 3

Cytoband

 p22.3

Chromosome location (bp)

 32685145 - 32773875

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000182973 (version 83.38)

Entrez gene

 25904

UniProt

 Q9H9A5 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9H9A5

Antibodypedia

 CNOT10 antibodies

PROTEIN BROWSER
CNOT10-001
CNOT10-003
CNOT10-012
CNOT10-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CNOT10-001
ENSP00000330060
ENST00000328834
Q9H9A5 [Direct mapping]
CCR4-NOT transcription complex subunit 10
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   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000288 [nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay]
GO:0000289 [nuclear-transcribed mRNA poly(A) tail shortening]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006417 [regulation of translation]
GO:0010467 [gene expression]
GO:0016020 [membrane]
GO:0030014 [CCR4-NOT complex]
GO:0031047 [gene silencing by RNA]
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 744 aa
82.3 kDa 		No 0
CNOT10-003
ENSP00000329376
ENST00000331889
Q9H9A5 [Direct mapping]
CCR4-NOT transcription complex subunit 10
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   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000288 [nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay]
GO:0000289 [nuclear-transcribed mRNA poly(A) tail shortening]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006417 [regulation of translation]
GO:0010467 [gene expression]
GO:0016020 [membrane]
GO:0030014 [CCR4-NOT complex]
GO:0031047 [gene silencing by RNA]
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 717 aa
79.4 kDa 		No 0
CNOT10-012
ENSP00000395385
ENST00000430408
H7C0K1 [Direct mapping]
CCR4-NOT transcription complex subunit 10
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   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 229 aa
24.7 kDa 		No 0
CNOT10-201
ENSP00000399862
ENST00000454516
Q9H9A5 [Direct mapping]
CCR4-NOT transcription complex subunit 10
Show all
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000288 [nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay]
GO:0000289 [nuclear-transcribed mRNA poly(A) tail shortening]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006417 [regulation of translation]
GO:0010467 [gene expression]
GO:0016020 [membrane]
GO:0030014 [CCR4-NOT complex]
GO:0031047 [gene silencing by RNA]
Show all
 804 aa
89.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.