Expression of CADM1 in cancer - Summary

GENERAL INFORMATION
Gene name	CADM1
Gene description	Cell adhesion molecule 1
Protein class	Plasma proteins Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	15
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (CACO-2, WM-115)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Membranous expression in most glandular cells, high abundance in CNS, testis and islets of Langerhans with basolateral membrane expression in renal tubules.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 1 antibody. CAB037266
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (favourable).
Endometrial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

CAB037266

GENE INFORMATION
Gene name	CADM1 (HGNC Symbol)
Synonyms	BL2, IGSF4, IGSF4A, Necl-2, NECL2, RA175, ST17, SYNCAM, SYNCAM1, TSLC1
Description	Cell adhesion molecule 1 (HGNC Symbol)
Entrez gene summary
Chromosome	11
Cytoband	q23.3
Chromosome location (bp)	115169218 - 115504957
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000182985 (version 83.38)
Entrez gene	23705
UniProt	Q9BY67 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BY67
Antibodypedia	CADM1 antibodies

PROTEIN BROWSER

CADM1-001	CADM1-002	CADM1-003	CADM1-005	CADM1-006	CADM1-008	CADM1-010	CADM1-013	CADM1-014	CADM1-015	CADM1-201	CADM1-202	CADM1-203	CADM1-204	CADM1-205

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CADM1-001 ENSP00000395359 ENST00000452722	Q9BY67 [Direct mapping] Cell adhesion molecule 1 X5D8W0 [Target identity:100%; Query identity:100%] Cell adhesion molecule 1 isoform D Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004872 [receptor activity] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005911 [cell-cell junction] GO:0005913 [cell-cell adherens junction] GO:0006915 [apoptotic process] GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules] GO:0007157 [heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules] GO:0007275 [multicellular organismal development] GO:0007283 [spermatogenesis] GO:0008037 [cell recognition] GO:0016323 [basolateral plasma membrane] GO:0030154 [cell differentiation] GO:0030165 [PDZ domain binding] GO:0034329 [cell junction assembly] GO:0034332 [adherens junction organization] GO:0042271 [susceptibility to natural killer cell mediated cytotoxicity] GO:0042803 [protein homodimerization activity] GO:0045202 [synapse] GO:0045216 [cell-cell junction organization] GO:0045954 [positive regulation of natural killer cell mediated cytotoxicity] GO:0050715 [positive regulation of cytokine secretion] GO:0050839 [cell adhesion molecule binding] GO:0051606 [detection of stimulus] GO:0070062 [extracellular exosome] Show all	442 aa 48.5 kDa	Yes	1
CADM1-002 ENSP00000439176 ENST00000542447	Q9BY67 [Direct mapping] Cell adhesion molecule 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004872 [receptor activity] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005911 [cell-cell junction] GO:0005913 [cell-cell adherens junction] GO:0006915 [apoptotic process] GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules] GO:0007157 [heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules] GO:0007275 [multicellular organismal development] GO:0007283 [spermatogenesis] GO:0008037 [cell recognition] GO:0016323 [basolateral plasma membrane] GO:0030154 [cell differentiation] GO:0030165 [PDZ domain binding] GO:0034329 [cell junction assembly] GO:0034332 [adherens junction organization] GO:0042271 [susceptibility to natural killer cell mediated cytotoxicity] GO:0042803 [protein homodimerization activity] GO:0045202 [synapse] GO:0045216 [cell-cell junction organization] GO:0045954 [positive regulation of natural killer cell mediated cytotoxicity] GO:0050715 [positive regulation of cytokine secretion] GO:0050839 [cell adhesion molecule binding] GO:0051606 [detection of stimulus] GO:0070062 [extracellular exosome] Show all	414 aa 45.6 kDa	Yes	1
CADM1-003 ENSP00000329797 ENST00000331581	Q9BY67 [Direct mapping] Cell adhesion molecule 1 X5D7A8 [Target identity:100%; Query identity:100%] Cell adhesion molecule 1 isoform A Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004872 [receptor activity] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005911 [cell-cell junction] GO:0005913 [cell-cell adherens junction] GO:0006915 [apoptotic process] GO:0007155 [cell adhesion] GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules] GO:0007157 [heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules] GO:0007275 [multicellular organismal development] GO:0007283 [spermatogenesis] GO:0007416 [synapse assembly] GO:0008021 [synaptic vesicle] GO:0008037 [cell recognition] GO:0009826 [unidimensional cell growth] GO:0016323 [basolateral plasma membrane] GO:0016338 [calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules] GO:0030154 [cell differentiation] GO:0030165 [PDZ domain binding] GO:0030424 [axon] GO:0030425 [dendrite] GO:0034329 [cell junction assembly] GO:0034332 [adherens junction organization] GO:0042271 [susceptibility to natural killer cell mediated cytotoxicity] GO:0042803 [protein homodimerization activity] GO:0043196 [varicosity] GO:0045202 [synapse] GO:0045216 [cell-cell junction organization] GO:0045954 [positive regulation of natural killer cell mediated cytotoxicity] GO:0050715 [positive regulation of cytokine secretion] GO:0050839 [cell adhesion molecule binding] GO:0051606 [detection of stimulus] GO:0060348 [bone development] GO:0070062 [extracellular exosome] GO:0070852 [cell body fiber] Show all	471 aa 51.5 kDa	Yes	1
CADM1-005 ENSP00000439817 ENST00000537058	Q9BY67 [Direct mapping] Cell adhesion molecule 1 X5DQR8 [Target identity:100%; Query identity:100%] Cell adhesion molecule 1 isoform B Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004872 [receptor activity] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005911 [cell-cell junction] GO:0005913 [cell-cell adherens junction] GO:0006915 [apoptotic process] GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules] GO:0007157 [heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules] GO:0007275 [multicellular organismal development] GO:0007283 [spermatogenesis] GO:0008037 [cell recognition] GO:0016323 [basolateral plasma membrane] GO:0030154 [cell differentiation] GO:0030165 [PDZ domain binding] GO:0034329 [cell junction assembly] GO:0034332 [adherens junction organization] GO:0042271 [susceptibility to natural killer cell mediated cytotoxicity] GO:0042803 [protein homodimerization activity] GO:0045202 [synapse] GO:0045216 [cell-cell junction organization] GO:0045954 [positive regulation of natural killer cell mediated cytotoxicity] GO:0050715 [positive regulation of cytokine secretion] GO:0050839 [cell adhesion molecule binding] GO:0051606 [detection of stimulus] GO:0070062 [extracellular exosome] Show all	453 aa 49.6 kDa	Yes	1
CADM1-006 ENSP00000440322 ENST00000536727	X5DQS5 [Direct mapping] Cell adhesion molecule 1; Cell adhesion molecule 1 isoform C Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	443 aa 48.6 kDa	Yes	1
CADM1-008 ENSP00000442387 ENST00000545380	A0A0A0MTJ8 [Direct mapping] Cell adhesion molecule 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	413 aa 45.4 kDa	Yes	1
CADM1-010 ENSP00000442227 ENST00000543249	H0YG94 [Direct mapping] Cell adhesion molecule 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	189 aa 21.1 kDa	No	0
CADM1-013 ENSP00000439847 ENST00000543540	F5H0H5 [Direct mapping] Cell adhesion molecule 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	79 aa 8.9 kDa	No	0
CADM1-014 ENSP00000439696 ENST00000545094	F5H125 [Direct mapping] Cell adhesion molecule 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	182 aa 20.5 kDa	No	0
CADM1-015 ENSP00000442001 ENST00000542450	F5H8J9 [Direct mapping] Cell adhesion molecule 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	111 aa 12.7 kDa	No	0
CADM1-201 ENSP00000483648 ENST00000612235	A0A087X0T8 [Direct mapping] Cell adhesion molecule 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	346 aa 38.8 kDa	No	1
CADM1-202 ENSP00000483793 ENST00000612471	A0A087X105 [Direct mapping] Cell adhesion molecule 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	373 aa 41.7 kDa	No	1
CADM1-203 ENSP00000484516 ENST00000616271	A0A087X1W8 [Direct mapping] Cell adhesion molecule 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	412 aa 45.7 kDa	No	1
CADM1-204 ENSP00000482840 ENST00000621043	A0A087WZR6 [Direct mapping] Cell adhesion molecule 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	430 aa 47.6 kDa	No	1
CADM1-205 ENSP00000482924 ENST00000621709	A0A087WZW4 [Direct mapping] Cell adhesion molecule 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	401 aa 44.6 kDa	No	1