Tissue expression of PYCR1 - Summary - The Human Protein Atlas

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PYCR1

TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	PYCR1
Gene description	Pyrroline-5-carboxylate reductase 1
Protein class	Disease related genes Enzymes Potential drug targets Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	17
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Mixed
GTEx:	Expressed in all
FANTOM5:	Group enriched (pancreas, salivary gland)

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in most tissues.

DATA RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA047660
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Mixed
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Group enriched (pancreas, salivary gland)

GENE INFORMATION
Gene name	PYCR1 (HGNC Symbol)
Synonyms	P5C
Description	Pyrroline-5-carboxylate reductase 1 (HGNC Symbol)
Entrez gene summary	This gene encodes an enzyme that catalyzes the NAD(P)H-dependent conversion of pyrroline-5-carboxylate to proline. This enzyme may also play a physiologic role in the generation of NADP(+) in some cell types. The protein forms a homopolymer and localizes to the mitochondrion. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Chromosome	17
Cytoband	q25.3
Chromosome location (bp)	81932384 - 81942412
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000183010 (version 83.38)
Entrez gene	5831
UniProt	P32322 (UniProt - Evidence at protein level)
neXtProt	NX_P32322
Antibodypedia	PYCR1 antibodies

PROTEIN BROWSER

PYCR1-001	PYCR1-002	PYCR1-003	PYCR1-005	PYCR1-006	PYCR1-007	PYCR1-008	PYCR1-009	PYCR1-010	PYCR1-011	PYCR1-012	PYCR1-013	PYCR1-014	PYCR1-015	PYCR1-016	PYCR1-201	PYCR1-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PYCR1-001 ENSP00000328858 ENST00000329875	P32322 [Direct mapping] Pyrroline-5-carboxylate reductase 1, mitochondrial A0A024R8U9 [Target identity:100%; Query identity:100%] Pyrroline-5-carboxylate reductase Show all	Enzymes ENZYME proteins Oxidoreductases SPOCTOPUS predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004735 [pyrroline-5-carboxylate reductase activity] GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0006561 [proline biosynthetic process] GO:0008652 [cellular amino acid biosynthetic process] GO:0034599 [cellular response to oxidative stress] GO:0034641 [cellular nitrogen compound metabolic process] GO:0042802 [identical protein binding] GO:0044281 [small molecule metabolic process] GO:0051881 [regulation of mitochondrial membrane potential] GO:0055114 [oxidation-reduction process] GO:0055129 [L-proline biosynthetic process] GO:1903206 [negative regulation of hydrogen peroxide-induced cell death] Show all	319 aa 33.4 kDa	No	0
PYCR1-002 ENSP00000336579 ENST00000337943	P32322 [Direct mapping] Pyrroline-5-carboxylate reductase 1, mitochondrial Show all	Enzymes ENZYME proteins Oxidoreductases SPOCTOPUS predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004735 [pyrroline-5-carboxylate reductase activity] GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0006561 [proline biosynthetic process] GO:0008652 [cellular amino acid biosynthetic process] GO:0034599 [cellular response to oxidative stress] GO:0034641 [cellular nitrogen compound metabolic process] GO:0042802 [identical protein binding] GO:0044281 [small molecule metabolic process] GO:0051881 [regulation of mitochondrial membrane potential] GO:0055114 [oxidation-reduction process] GO:0055129 [L-proline biosynthetic process] GO:1903206 [negative regulation of hydrogen peroxide-induced cell death] Show all	316 aa 33.3 kDa	No	0
PYCR1-003 ENSP00000384949 ENST00000402252	P32322 [Direct mapping] Pyrroline-5-carboxylate reductase 1, mitochondrial Show all	Enzymes ENZYME proteins Oxidoreductases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0004735 [pyrroline-5-carboxylate reductase activity] GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0006561 [proline biosynthetic process] GO:0008652 [cellular amino acid biosynthetic process] GO:0034599 [cellular response to oxidative stress] GO:0034641 [cellular nitrogen compound metabolic process] GO:0042802 [identical protein binding] GO:0044281 [small molecule metabolic process] GO:0051881 [regulation of mitochondrial membrane potential] GO:0055114 [oxidation-reduction process] GO:0055129 [L-proline biosynthetic process] GO:1903206 [negative regulation of hydrogen peroxide-induced cell death] Show all	346 aa 36 kDa	No	0
PYCR1-005 ENSP00000385483 ENST00000403172	E2QRB3 [Direct mapping] Pyrroline-5-carboxylate reductase 1, isoform CRA_c; Pyrroline-5-carboxylate reductase 1, mitochondrial Show all	Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004735 [pyrroline-5-carboxylate reductase activity] GO:0006561 [proline biosynthetic process] GO:0055114 [oxidation-reduction process] Show all	288 aa 30.2 kDa	No	0
PYCR1-006 ENSP00000463226 ENST00000582198	J3QKT4 [Direct mapping] Pyrroline-5-carboxylate reductase Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004735 [pyrroline-5-carboxylate reductase activity] GO:0006561 [proline biosynthetic process] GO:0055114 [oxidation-reduction process] GO:0055129 [L-proline biosynthetic process] Show all	242 aa 25.6 kDa	No	0
PYCR1-007 ENSP00000462398 ENST00000579366	J3KSA9 [Direct mapping] Pyrroline-5-carboxylate reductase 1, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004735 [pyrroline-5-carboxylate reductase activity] GO:0006561 [proline biosynthetic process] GO:0055114 [oxidation-reduction process] Show all	109 aa 11.8 kDa	No	0
PYCR1-008 ENSP00000464440 ENST00000581271	J3QRZ0 [Direct mapping] Pyrroline-5-carboxylate reductase 1, mitochondrial Show all	TMHMM predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004735 [pyrroline-5-carboxylate reductase activity] GO:0006561 [proline biosynthetic process] GO:0055114 [oxidation-reduction process] Show all	115 aa 12.1 kDa	No	0
PYCR1-009 ENSP00000464098 ENST00000577624	J3QR88 [Direct mapping] Pyrroline-5-carboxylate reductase 1, mitochondrial Show all	TMHMM predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004735 [pyrroline-5-carboxylate reductase activity] GO:0006561 [proline biosynthetic process] GO:0055114 [oxidation-reduction process] Show all	132 aa 13.5 kDa	No	0
PYCR1-010 ENSP00000463343 ENST00000585215	J3QL24 [Direct mapping] Pyrroline-5-carboxylate reductase 1, mitochondrial Show all	Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004735 [pyrroline-5-carboxylate reductase activity] GO:0006561 [proline biosynthetic process] GO:0055114 [oxidation-reduction process] Show all	225 aa 23.6 kDa	No	0
PYCR1-011 ENSP00000386002 ENST00000405481	J3KQ22 [Direct mapping] Pyrroline-5-carboxylate reductase Show all	SPOCTOPUS predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004735 [pyrroline-5-carboxylate reductase activity] GO:0006561 [proline biosynthetic process] GO:0055114 [oxidation-reduction process] GO:0055129 [L-proline biosynthetic process] Show all	253 aa 26.4 kDa	No	0
PYCR1-012 ENSP00000463601 ENST00000579698	J3QLK9 [Direct mapping] Pyrroline-5-carboxylate reductase 1, mitochondrial Show all	SPOCTOPUS predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004735 [pyrroline-5-carboxylate reductase activity] GO:0006561 [proline biosynthetic process] GO:0055114 [oxidation-reduction process] Show all	165 aa 17.6 kDa	No	0
PYCR1-013 ENSP00000462892 ENST00000585244	J3KTA8 [Direct mapping] Pyrroline-5-carboxylate reductase 1, mitochondrial Show all	TMHMM predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004735 [pyrroline-5-carboxylate reductase activity] GO:0006561 [proline biosynthetic process] GO:0055114 [oxidation-reduction process] Show all	84 aa 8.8 kDa	No	0
PYCR1-014 ENSP00000463225 ENST00000583564	J3QKT3 [Direct mapping] Pyrroline-5-carboxylate reductase 1, mitochondrial Show all	TMHMM predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004735 [pyrroline-5-carboxylate reductase activity] GO:0006561 [proline biosynthetic process] GO:0055114 [oxidation-reduction process] Show all	94 aa 9.9 kDa	No	0
PYCR1-015 ENSP00000463352 ENST00000577756	J3QL32 [Direct mapping] Pyrroline-5-carboxylate reductase 1, isoform CRA_a; Pyrroline-5-carboxylate reductase 1, mitochondrial Show all	Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004735 [pyrroline-5-carboxylate reductase activity] GO:0006561 [proline biosynthetic process] GO:0055114 [oxidation-reduction process] Show all	217 aa 22.6 kDa	No	0
PYCR1-016 ENSP00000463342 ENST00000584848	J3QL23 [Direct mapping] Pyrroline-5-carboxylate reductase 1, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004735 [pyrroline-5-carboxylate reductase activity] GO:0006561 [proline biosynthetic process] GO:0055114 [oxidation-reduction process] Show all	173 aa 18.2 kDa	No	0
PYCR1-201 ENSP00000479793 ENST00000619204	P32322 [Direct mapping] Pyrroline-5-carboxylate reductase 1, mitochondrial A0A024R8U9 [Target identity:100%; Query identity:100%] Pyrroline-5-carboxylate reductase Show all	Enzymes ENZYME proteins Oxidoreductases SPOCTOPUS predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0004735 [pyrroline-5-carboxylate reductase activity] GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0006561 [proline biosynthetic process] GO:0008652 [cellular amino acid biosynthetic process] GO:0034599 [cellular response to oxidative stress] GO:0034641 [cellular nitrogen compound metabolic process] GO:0042802 [identical protein binding] GO:0044281 [small molecule metabolic process] GO:0051881 [regulation of mitochondrial membrane potential] GO:0055114 [oxidation-reduction process] GO:0055129 [L-proline biosynthetic process] GO:1903206 [negative regulation of hydrogen peroxide-induced cell death] Show all	319 aa 33.4 kDa	No	0
PYCR1-202 ENSP00000485679 ENST00000629768	J3QL32 [Direct mapping] Pyrroline-5-carboxylate reductase 1, isoform CRA_a; Pyrroline-5-carboxylate reductase 1, mitochondrial Show all	Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004735 [pyrroline-5-carboxylate reductase activity] GO:0006561 [proline biosynthetic process] GO:0055114 [oxidation-reduction process] Show all	217 aa 22.6 kDa	No	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.