Expression of MCEMP1 in cancer - Summary - The Human Protein Atlas

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MCEMP1

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	MCEMP1
Gene description	Mast cell-expressed membrane protein 1
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Group enriched (THP-1, U-937)
HPA (normal tissue):	Group enriched (appendix, bone marrow, lung)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in subsets of immune cells in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Antibody staining in cells/structures not annotated, view images.
Reliability score	Supported based on 1 antibody. HPA014731
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA014731

GENE INFORMATION
Gene name	MCEMP1 (HGNC Symbol)
Synonyms	C19orf59, MGC132456
Description	Mast cell-expressed membrane protein 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a single-pass transmembrane protein. Based on its expression pattern, it is speculated to be involved in regulating mast cell differentiation or immune responses. [provided by RefSeq, Jul 2008]
Chromosome	19
Cytoband	p13.2
Chromosome location (bp)	7676628 - 7679826
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000183019 (version 83.38)
Entrez gene	199675
UniProt	Q8IX19 (UniProt - Evidence at protein level)
neXtProt	NX_Q8IX19
Antibodypedia	MCEMP1 antibodies

PROTEIN BROWSER

MCEMP1-001	MCEMP1-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MCEMP1-001 ENSP00000329920 ENST00000333598	Q8IX19 [Direct mapping] Mast cell-expressed membrane protein 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	187 aa 21.2 kDa	No	1
MCEMP1-002 ENSP00000471413 ENST00000597445	M0R0S5 [Direct mapping] Mast cell-expressed membrane protein 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	144 aa 16.3 kDa	No	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.