Expression of PCP4 in cancer - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	PCP4
Gene description	Purkinje cell protein 4
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (RPMI-8226, SK-BR-3, T-47d)
HPA (normal tissue):	Tissue enhanced (prostate, seminal vesicle)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and nuclear expression in most neuronal cells in CNS and in smooth muscle cells in male reproductive organs.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining in cells/structures not annotated, view images.
Reliability score	Supported based on 1 antibody. HPA005792
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and cervical cancer (favourable).
Renal cancer p<0.001 Cervical cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

STAINING SUMMARY

HPA005792

GENE INFORMATION
Gene name	PCP4 (HGNC Symbol)
Synonyms	PEP-19
Description	Purkinje cell protein 4 (HGNC Symbol)
Entrez gene summary
Chromosome	21
Cytoband	q22.2
Chromosome location (bp)	39867317 - 39929397
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000183036 (version 83.38)
Entrez gene	5121
UniProt	P48539 (UniProt - Evidence at protein level)
neXtProt	NX_P48539
Antibodypedia	PCP4 antibodies

PROTEIN BROWSER

PCP4-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PCP4-001 ENSP00000329403 ENST00000328619	P48539 [Direct mapping] Purkinje cell protein 4 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001649 [osteoblast differentiation] GO:0003723 [RNA binding] GO:0005516 [calmodulin binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005883 [neurofilament] GO:0006469 [negative regulation of protein kinase activity] GO:0006970 [response to osmotic stress] GO:0007417 [central nervous system development] GO:0010976 [positive regulation of neuron projection development] GO:0030424 [axon] GO:0033603 [positive regulation of dopamine secretion] GO:0043005 [neuron projection] GO:0043524 [negative regulation of neuron apoptotic process] GO:1904009 [cellular response to monosodium glutamate] Show all	62 aa 6.8 kDa	No	0