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SLC25A10

GENERAL INFORMATION

Gene name

 SLC25A10

Gene description

 Solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10

Protein class

 Predicted intracellular proteins
Predicted membrane proteins
Transporters

Predicted localization

 Intracellular,Membrane

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression with a granular pattern.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification. Caution, targets protein from more than one gene.

Reliability score

 Supported based on 1 antibody.
HPA023048
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PROGNOSTIC SUMMARY
Prognostic marker in urothelial cancer (favourable), head and neck cancer (favourable) and ovarian cancer (favourable).
Urothelial cancer p<0.001
Head and neck cancer p<0.001
Ovarian cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA023048

GENE INFORMATION

Gene name

 SLC25A10 (HGNC Symbol)

Synonyms

 DIC

Description

 Solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of a family of proteins that translocate small metabolites across the mitochondrial membrane. The encoded protein exchanges dicarboxylates, such as malate and succinate, for phosphate, sulfate, and other small molecules, thereby providing substrates for metabolic processes including the Krebs cycle and fatty acid synthesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]

Chromosome

 17

Cytoband

 q25.3

Chromosome location (bp)

 81712236 - 81721016

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000183048 (version 83.38)

Entrez gene

 1468

UniProt

 Q9UBX3 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UBX3

Antibodypedia

 SLC25A10 antibodies

PROTEIN BROWSER
SLC25A10-001
SLC25A10-002
SLC25A10-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SLC25A10-001
ENSP00000328403
ENST00000331531
Q9UBX3 [Direct mapping]
Mitochondrial dicarboxylate carrier
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Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
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GO:0000096 [sulfur amino acid metabolic process]
GO:0000098 [sulfur amino acid catabolic process]
GO:0005310 [dicarboxylic acid transmembrane transporter activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005743 [mitochondrial inner membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0006006 [glucose metabolic process]
GO:0006094 [gluconeogenesis]
GO:0006811 [ion transport]
GO:0006835 [dicarboxylic acid transport]
GO:0006839 [mitochondrial transport]
GO:0016021 [integral component of membrane]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0055085 [transmembrane transport]
GO:0070221 [sulfide oxidation, using sulfide:quinone oxidoreductase]
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 296 aa
32.1 kDa 		No 3
SLC25A10-002
ENSP00000345580
ENST00000350690
Q9UBX3 [Direct mapping]
Mitochondrial dicarboxylate carrier
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Transporters
   Electrochemical Potential-driven transporters
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000096 [sulfur amino acid metabolic process]
GO:0000098 [sulfur amino acid catabolic process]
GO:0005310 [dicarboxylic acid transmembrane transporter activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005743 [mitochondrial inner membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0006006 [glucose metabolic process]
GO:0006094 [gluconeogenesis]
GO:0006811 [ion transport]
GO:0006835 [dicarboxylic acid transport]
GO:0006839 [mitochondrial transport]
GO:0016021 [integral component of membrane]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0055085 [transmembrane transport]
GO:0070221 [sulfide oxidation, using sulfide:quinone oxidoreductase]
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 287 aa
31.3 kDa 		No 0
SLC25A10-201
ENSP00000446242
ENST00000545862
F6RGN5 [Direct mapping]
Mitochondrial dicarboxylate carrier
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   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0006810 [transport]
GO:0016021 [integral component of membrane]
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 406 aa
43.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.