Cell atlas - CAMK1D - The Human Protein Atlas

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CAMK1D

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS MOUSE CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nucleus

Human cell
	Cytosol
	Nucleoplasm

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GENERAL INFORMATION
Gene name	CAMK1D
Gene description	Calcium/calmodulin-dependent protein kinase ID
Protein class	Enzymes Plasma proteins Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleus & cytosol.
RNA cell category	Cell line enhanced (HDLM-2, U-266/70)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleus (approved), Cytosol (approved)
Mouse	Localized to the Nucleoplasm in mouse cells.

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA007266
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (HDLM-2, U-266/70) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleus & cytosol.

Main location

Nucleus (approved), Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA007266	A-431	Cytosol
	HPA007266	U-2 OS	No staining
	HPA007266	U-251 MG	Nucleus

MOUSE CELLS

Main location

Nucleoplasm

Additional location

Cytosol

Mouse gene

ENSMUSG00000039145 (version 83)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location
	HPA007266	NIH 3T3	Nucleoplasm
	HPA007266	NIH 3T3	Cytosol

GENE INFORMATION
Gene name	CAMK1D (HGNC Symbol)
Synonyms	CKLiK
Description	Calcium/calmodulin-dependent protein kinase ID (HGNC Symbol)
Entrez gene summary	This gene is a member of the calcium/calmodulin-dependent protein kinase 1 family, a subfamily of the serine/threonine kinases. The encoded protein is a component of the calcium-regulated calmodulin-dependent protein kinase cascade. It has been associated with multiple processes including regulation of granulocyte function, activation of CREB-dependent gene transcription, aldosterone synthesis, differentiation and activation of neutrophil cells, and apoptosis of erythroleukemia cells. Alternatively spliced transcript variants encoding different isoforms of this gene have been described. [provided by RefSeq, Jan 2015]
Chromosome	10
Cytoband	p13
Chromosome location (bp)	12349482 - 12835545
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000183049 (version 83.38)
Entrez gene	57118
UniProt	Q8IU85 (UniProt - Evidence at protein level)
neXtProt	NX_Q8IU85
Antibodypedia	CAMK1D antibodies

PROTEIN BROWSER

CAMK1D-001	CAMK1D-002	CAMK1D-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CAMK1D-001 ENSP00000478874 ENST00000619168	Q8IU85 [Direct mapping] Calcium/calmodulin-dependent protein kinase type 1D Show all	Enzymes ENZYME proteins Transferases Kinases CAMK Ser/Thr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004683 [calmodulin-dependent protein kinase activity] GO:0005516 [calmodulin binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006468 [protein phosphorylation] GO:0006954 [inflammatory response] GO:0010976 [positive regulation of neuron projection development] GO:0032793 [positive regulation of CREB transcription factor activity] GO:0043065 [positive regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0050766 [positive regulation of phagocytosis] GO:0050773 [regulation of dendrite development] GO:0060267 [positive regulation of respiratory burst] GO:0071622 [regulation of granulocyte chemotaxis] GO:0090023 [positive regulation of neutrophil chemotaxis] Show all	385 aa 42.9 kDa	No	1
CAMK1D-002 ENSP00000368122 ENST00000378845	Q8IU85 [Direct mapping] Calcium/calmodulin-dependent protein kinase type 1D Q5SQQ7 [Target identity:100%; Query identity:100%] Calcium/calmodulin-dependent protein kinase ID, isoform CRA_b; Calcium/calmodulin-dependent protein kinase type 1D variant 2; Calcium/calmodulin-dependent protein kinase type 1D variant 3; cDNA FLJ76987, highly similar to Homo sapiens calcium/calmodulin-dependent protein kinase ID (CAMK1D), transcript variant 1, mRNA Show all	Enzymes ENZYME proteins Transferases Kinases CAMK Ser/Thr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004683 [calmodulin-dependent protein kinase activity] GO:0005516 [calmodulin binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006468 [protein phosphorylation] GO:0006954 [inflammatory response] GO:0010976 [positive regulation of neuron projection development] GO:0032793 [positive regulation of CREB transcription factor activity] GO:0050766 [positive regulation of phagocytosis] GO:0050773 [regulation of dendrite development] GO:0060267 [positive regulation of respiratory burst] GO:0071622 [regulation of granulocyte chemotaxis] GO:0090023 [positive regulation of neutrophil chemotaxis] Show all	357 aa 40.2 kDa	No	1
CAMK1D-201 ENSP00000478861 ENST00000615792	A0A087WUR6 [Direct mapping] Calcium/calmodulin-dependent protein kinase type 1D Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	291 aa 32.5 kDa	No	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.