Expression of FREM3 in cancer - Summary - The Human Protein Atlas

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FREM3

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	FREM3
Gene description	FRAS1 related extracellular matrix 3
Protein class	Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Not detected
HPA (cell line):	Not detected
HPA (normal tissue):	Tissue enhanced (cerebral cortex)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification. Antibody staining not consistent with RNA expression data.
Reliability score	Uncertain based on 1 antibody. HPA041641
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Not detected

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA041641

GENE INFORMATION
Gene name	FREM3
Synonyms
Description	FRAS1 related extracellular matrix 3 (HGNC Symbol)
Entrez gene summary
Chromosome	4
Cytoband	q31.21
Chromosome location (bp)	143577302 - 143700675
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000183090 (version 83.38)
Entrez gene	166752
UniProt	P0C091 (UniProt - Inferred from homology)
neXtProt	NX_P0C091
Antibodypedia	FREM3 antibodies

PROTEIN BROWSER

FREM3-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FREM3-001 ENSP00000332886 ENST00000329798	P0C091 [Direct mapping] FRAS1-related extracellular matrix protein 3 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Show all	GO:0005604 [basement membrane] GO:0005615 [extracellular space] GO:0007154 [cell communication] GO:0007155 [cell adhesion] GO:0016021 [integral component of membrane] GO:0031012 [extracellular matrix] GO:0046872 [metal ion binding] Show all	2139 aa 238.2 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.