Expression of BEGAIN in cancer - Summary - The Human Protein Atlas

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BEGAIN

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	BEGAIN
Gene description	Brain-enriched guanylate kinase-associated
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Group enriched (HeLa, SH-SY5Y)
HPA (normal tissue):	Tissue enhanced (cerebral cortex)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues, most abundant in CNS.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining not consistent with RNA expression data. Presumed off target binding observed and disregarded.
Reliability score	Uncertain based on 1 antibody. HPA002899
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA002899

GENE INFORMATION
Gene name	BEGAIN (HGNC Symbol)
Synonyms	KIAA1446
Description	Brain-enriched guanylate kinase-associated (HGNC Symbol)
Entrez gene summary
Chromosome	14
Cytoband	q32.2
Chromosome location (bp)	100537149 - 100587413
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000183092 (version 83.38)
Entrez gene	57596
UniProt	Q9BUH8 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BUH8
Antibodypedia	BEGAIN antibodies

PROTEIN BROWSER

BEGAIN-001	BEGAIN-002	BEGAIN-003	BEGAIN-005	BEGAIN-006	BEGAIN-007	BEGAIN-008	BEGAIN-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
BEGAIN-001 ENSP00000347301 ENST00000355173	Q9BUH8 [Direct mapping] Brain-enriched guanylate kinase-associated protein Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0016020 [membrane] Show all	593 aa 64.8 kDa	No	0
BEGAIN-002 ENSP00000451380 ENST00000556751	G3V3R5 [Direct mapping] Brain-enriched guanylate kinase-associated protein; Likely ortholog of rat brain-enriched guanylate kinase-associated protein, isoform CRA_a Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0016301 [kinase activity] GO:0016310 [phosphorylation] Show all	529 aa 57 kDa	No	0
BEGAIN-003 ENSP00000452157 ENST00000556188	G3V536 [Direct mapping] Brain-enriched guanylate kinase-associated protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		288 aa 32.9 kDa	No	0
BEGAIN-005 ENSP00000451397 ENST00000553553	G3V3S3 [Direct mapping] Brain-enriched guanylate kinase-associated protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		300 aa 34 kDa	No	0
BEGAIN-006 ENSP00000451125 ENST00000554140	G3V3A2 [Direct mapping] Brain-enriched guanylate kinase-associated protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		169 aa 19.9 kDa	No	0
BEGAIN-007 ENSP00000450722 ENST00000557378	G3V2K4 [Direct mapping] Brain-enriched guanylate kinase-associated protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		168 aa 19.9 kDa	No	0
BEGAIN-008 ENSP00000452607 ENST00000554356	G3V600 [Direct mapping] Brain-enriched guanylate kinase-associated protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		175 aa 19.7 kDa	No	0
BEGAIN-201 ENSP00000411124 ENST00000443071	Q9BUH8 [Direct mapping] Brain-enriched guanylate kinase-associated protein Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0016020 [membrane] Show all	593 aa 64.8 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.