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RABIF

GENERAL INFORMATION

Gene name

 RABIF

Gene description

 RAB interacting factor

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic and nuclear expression in all tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA027715
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), ovarian cancer (favourable) and liver cancer (unfavourable).
Renal cancer p<0.001
Ovarian cancer p<0.001
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA027715

GENE INFORMATION

Gene name

 RABIF (HGNC Symbol)

Synonyms

 mss4, RASGRF3

Description

 RAB interacting factor (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the SCE4/YPT1/RAB family of small GTP-binding proteins that are involved in the regulation of intracellular vesicular transport. This protein stimulates GTP-GDP exchange in SEC4, and to a lesser extent in YPT1 and RAB3A, and may play a general role in vesicular transport. [provided by RefSeq, Oct 2011]

Chromosome

 1

Cytoband

 q32.1

Chromosome location (bp)

 202878957 - 202889135

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000183155 (version 83.38)

Entrez gene

 5877

UniProt

 P47224 (UniProt - Evidence at protein level)

neXtProt

 NX_P47224

Antibodypedia

 RABIF antibodies

PROTEIN BROWSER
RABIF-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RABIF-001
ENSP00000356231
ENST00000367262
P47224 [Direct mapping]
Guanine nucleotide exchange factor MSS4
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008270 [zinc ion binding]
GO:0015031 [protein transport]
GO:0043547 [positive regulation of GTPase activity]
GO:0061025 [membrane fusion]
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 123 aa
13.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.