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FANCF

GENERAL INFORMATION

Gene name

 FANCF

Gene description

 Fanconi anemia, complementation group F

Protein class

 Cancer-related genes
Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed

Protein evidence

 Evidence at protein level

DATA RELIABILITY

Reliability score

 Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed

GENE INFORMATION

Gene name

 FANCF (HGNC Symbol)

Synonyms

 FAF

Description

 Fanconi anemia, complementation group F (HGNC Symbol)

Entrez gene summary

 The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group F. [provided by RefSeq, Jul 2008]

Chromosome

 11

Cytoband

 p14.3

Chromosome location (bp)

 22622519 - 22626787

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000183161 (version 83.38)

Entrez gene

 2188

UniProt

 Q9NPI8 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NPI8

Antibodypedia

 FANCF antibodies

PROTEIN BROWSER
FANCF-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FANCF-001
ENSP00000330875
ENST00000327470
Q9NPI8 [Direct mapping]
Fanconi anemia group F protein
A3KME0 [Target identity:100%; Query identity:100%]
Fanconi anemia, complementation group F; cDNA FLJ10854 fis, clone NT2RP4001507, highly similar to Fanconi anemia group F protein
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Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Nonsense Mutations
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001541 [ovarian follicle development]
GO:0003674 [molecular_function]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0006281 [DNA repair]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007283 [spermatogenesis]
GO:0008150 [biological_process]
GO:0016567 [protein ubiquitination]
GO:0036297 [interstrand cross-link repair]
GO:0043240 [Fanconi anaemia nuclear complex]
GO:0061630 [ubiquitin protein ligase activity]
GO:0098779 [mitophagy in response to mitochondrial depolarization]
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 374 aa
42.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.