We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
Most cancer tissues showed weak to moderate cytoplasmic and/or membranous positivity. Gliomas, lymphomas and renal cancers were negative in several cases.
Several urothelial, pancreas, thyroid, stomach cancers, few colorectal cancers and melanomas showed weak membranous/cytoplasmic positivity. Other cancer tissue were negative.
This gene encodes a protein that belongs to the vinculin/alpha-catenin family. The encoded protein plays a role in cell-cell adhesion in muscle cells. Mutations in this gene are associated with arrhythmogenic right ventricular dysplasia, familial 13. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005856 [cytoskeleton] GO:0005912 [adherens junction] GO:0005916 [fascia adherens] GO:0007155 [cell adhesion] GO:0008013 [beta-catenin binding] GO:0016337 [single organismal cell-cell adhesion] GO:0030027 [lamellipodium] GO:0045296 [cadherin binding] GO:0051015 [actin filament binding] GO:0086073 [bundle of His cell-Purkinje myocyte adhesion involved in cell communication] GO:0086083 [cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication] GO:0086091 [regulation of heart rate by cardiac conduction] GO:0098911 [regulation of ventricular cardiac muscle cell action potential]