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Moderate to strong cytoplasmic immunoreactivity with a granular pattern was observed in most malignant cells. Luminal membranous staining was observed in several cancers. Malignant lymphomas along with several skin and stomach cancers were weakly stained or negative.
GENE INFORMATION
Gene name
PTTG1IP (HGNC Symbol)
Synonyms
C21orf1, C21orf3, PBF
Description
Pituitary tumor-transforming 1 interacting protein (HGNC Symbol)
Entrez gene summary
This gene encodes a single-pass type I integral membrane protein, which binds to pituitary tumor-transforming 1 protein (PTTG1), and facilitates translocation of PTTG1 into the nucleus. Coexpression of this protein and PTTG1 induces transcriptional activation of basic fibroblast growth factor. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2013]
P53801 [Direct mapping] Pituitary tumor-transforming gene 1 protein-interacting protein
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Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0002039 [p53 binding] GO:0003674 [molecular_function] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006606 [protein import into nucleus] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0031398 [positive regulation of protein ubiquitination] GO:0043518 [negative regulation of DNA damage response, signal transduction by p53 class mediator] GO:0070062 [extracellular exosome] GO:1902254 [negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator] GO:1903364 [positive regulation of cellular protein catabolic process]