Expression of EPHA10 in cancer - Summary - The Human Protein Atlas

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EPHA10

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	EPHA10
Gene description	EPH receptor A10
Protein class	Enzymes Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (HDLM-2, SCLC-21H)
HPA (normal tissue):	Tissue enhanced (testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues, including Leydig cells in testis

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Presumed off target binding observed and disregarded.
Reliability score	Uncertain based on 1 antibody. HPA027497
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA027497

GENE INFORMATION
Gene name	EPHA10 (HGNC Symbol)
Synonyms	FLJ16103, FLJ33655
Description	EPH receptor A10 (HGNC Symbol)
Entrez gene summary	Ephrin receptors, the largest subfamily of receptor tyrosine kinases (RTKs), and their ephrin ligands are important mediators of cell-cell communication regulating cell attachment, shape, and mobility in neuronal and epithelial cells (Aasheim et al., 2005 [PubMed 15777695]). See MIM 179610 for additional background on Eph receptors and ephrins.[supplied by OMIM, Mar 2008]
Chromosome	1
Cytoband	p34.3
Chromosome location (bp)	37713880 - 37765133
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000183317 (version 83.38)
Entrez gene	284656
UniProt	Q5JZY3 (UniProt - Evidence at protein level)
neXtProt	NX_Q5JZY3
Antibodypedia	EPHA10 antibodies

PROTEIN BROWSER

EPHA10-001	EPHA10-003	EPHA10-201	EPHA10-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
EPHA10-001 ENSP00000316395 ENST00000319637	Q5JZY3 [Direct mapping] Ephrin type-A receptor 10 Show all	Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005003 [ephrin receptor activity] GO:0005005 [transmembrane-ephrin receptor activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006468 [protein phosphorylation] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007411 [axon guidance] GO:0008150 [biological_process] GO:0016021 [integral component of membrane] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0048013 [ephrin receptor signaling pathway] GO:0070062 [extracellular exosome] Show all	295 aa 32.1 kDa	Yes	0
EPHA10-003 ENSP00000362139 ENST00000373048	Q5JZY3 [Direct mapping] Ephrin type-A receptor 10 Show all	Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0005003 [ephrin receptor activity] GO:0005005 [transmembrane-ephrin receptor activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006468 [protein phosphorylation] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007411 [axon guidance] GO:0008150 [biological_process] GO:0016021 [integral component of membrane] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0048013 [ephrin receptor signaling pathway] GO:0070062 [extracellular exosome] Show all	1008 aa 109.7 kDa	Yes	1
EPHA10-201 ENSP00000397746 ENST00000427468	J3KQG3 [Direct mapping] EPH receptor A10, isoform CRA_b; Ephrin type-A receptor 10 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0005003 [ephrin receptor activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005887 [integral component of plasma membrane] GO:0006468 [protein phosphorylation] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0016021 [integral component of membrane] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0048013 [ephrin receptor signaling pathway] Show all	1014 aa 110.4 kDa	Yes	1
EPHA10-202 ENSP00000441822 ENST00000540011	F5GWI2 [Direct mapping] Ephrin type-A receptor 10 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	155 aa 16.6 kDa	No	1

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The Human Protein Atlas

The Human Protein Atlas project is funded
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