Expression of CCDC125 in cancer - Summary - The Human Protein Atlas

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CCDC125

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CCDC125
Gene description	Coiled-coil domain containing 125
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA041878
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PROGNOSTIC SUMMARY
Prognostic marker in urothelial cancer (favourable), endometrial cancer (favourable) and breast cancer (unfavourable).
Urothelial cancer p<0.001 Endometrial cancer p<0.001 Breast cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA041878

GENE INFORMATION
Gene name	CCDC125 (HGNC Symbol)
Synonyms	KENAE
Description	Coiled-coil domain containing 125 (HGNC Symbol)
Entrez gene summary
Chromosome	5
Cytoband	q13.2
Chromosome location (bp)	69280175 - 69332809
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000183323 (version 83.38)
Entrez gene	202243
UniProt	Q86Z20 (UniProt - Evidence at protein level)
neXtProt	NX_Q86Z20
Antibodypedia	CCDC125 antibodies

PROTEIN BROWSER

CCDC125-001	CCDC125-003	CCDC125-004	CCDC125-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CCDC125-001 ENSP00000379754 ENST00000396496	Q86Z20 [Direct mapping] Coiled-coil domain-containing protein 125 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0005737 [cytoplasm] Show all	511 aa 58.6 kDa	No	0
CCDC125-003 ENSP00000372865 ENST00000383374	F8W912 [Direct mapping] Coiled-coil domain-containing protein 125 Show all	Predicted intracellular proteins Show all		312 aa 36.2 kDa	No	0
CCDC125-004 ENSP00000426795 ENST00000511257	Q86Z20 [Direct mapping] Coiled-coil domain-containing protein 125 Show all	Predicted intracellular proteins Show all	GO:0005737 [cytoplasm] Show all	386 aa 44.2 kDa	No	0
CCDC125-201 ENSP00000379756 ENST00000396499	Q86Z20 [Direct mapping] Coiled-coil domain-containing protein 125 Show all	Predicted intracellular proteins Show all	GO:0005737 [cytoplasm] Show all	511 aa 58.6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.