Expression of PMCH in cancer - Summary - The Human Protein Atlas

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PMCH

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	PMCH
Gene description	Pro-melanin-concentrating hormone
Protein class	Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (endometrial cancer)
HPA (cell line):	Cell line enriched (HDLM-2)
HPA (normal tissue):	Tissue enhanced (lymph node)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Hihgly expressed in neurons and neural processes in hypothalamus.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with external characterization data and GTEx RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA046055 , HPA061884
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (endometrial cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA046055	HPA061884

GENE INFORMATION
Gene name	PMCH (HGNC Symbol)
Synonyms	MCH
Description	Pro-melanin-concentrating hormone (HGNC Symbol)
Entrez gene summary	This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include melanin-concentrating hormone (MCH), neuropeptide-glutamic acid-isoleucine (NEI), and neuropeptide-glycine-glutamic acid (NGE). Melanin-concentrating hormone is a 19-amino acid neuropeptide that stimulates hunger and may additionally regulate energy homeostasis, reproductive function, and sleep. Pseudogenes of this gene have been identified on chromosome 5. [provided by RefSeq, Jul 2015]
Chromosome	12
Cytoband	q23.2
Chromosome location (bp)	102196459 - 102197845
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000183395 (version 83.38)
Entrez gene	5367
UniProt	P20382 (UniProt - Evidence at protein level)
neXtProt	NX_P20382
Antibodypedia	PMCH antibodies

PROTEIN BROWSER

PMCH-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PMCH-001 ENSP00000332225 ENST00000329406	P20382 [Direct mapping] Pro-MCH Neuropeptide-glycine-glutamic acid Neuropeptide-glutamic acid-isoleucine Melanin-concentrating hormone Show all	MEMSAT3 predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005576 [extracellular region] GO:0005634 [nucleus] GO:0007218 [neuropeptide signaling pathway] GO:0007268 [synaptic transmission] GO:0007275 [multicellular organismal development] GO:0007283 [spermatogenesis] GO:0007631 [feeding behavior] GO:0030154 [cell differentiation] GO:0030354 [melanin-concentrating hormone activity] Show all	165 aa 18.7 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.