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MEX3B

GENERAL INFORMATION

Gene name

 MEX3B

Gene description

 Mex-3 RNA binding family member B

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (AN3-CA, HEL)
HPA (normal tissue):Tissue enhanced (testis)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in spermatozoa in testis.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Approved based on 1 antibody.
HPA041093
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA041093

GENE INFORMATION

Gene name

 MEX3B (HGNC Symbol)

Synonyms

 DKFZp434J0617, RKHD3, RNF195

Description

 Mex-3 RNA binding family member B (HGNC Symbol)

Entrez gene summary

 This gene encodes an RNA-binding phosphoprotein that is part of the MEX3 (muscle excess 3) family of translational regulators. The encoded protein contains N-terminal nuclear export and nuclear localization signals and is exported from the cytoplasm to the nucleus. The protein binds to RNA via two KH domains and also colocalizes with MEX3A, Dcp1A decapping factor and Argonaute proteins within P (processing) bodies. [provided by RefSeq, Oct 2012]

Chromosome

 15

Cytoband

 q25.2

Chromosome location (bp)

 82041778 - 82046141

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000183496 (version 83.38)

Entrez gene

 84206

UniProt

 Q6ZN04 (UniProt - Evidence at protein level)

neXtProt

 NX_Q6ZN04

Antibodypedia

 MEX3B antibodies

PROTEIN BROWSER
MEX3B-001
MEX3B-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MEX3B-001
ENSP00000329918
ENST00000329713
Q6ZN04 [Direct mapping]
RNA-binding protein MEX3B
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Predicted intracellular proteins
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GO:0000932 [cytoplasmic mRNA processing body]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006468 [protein phosphorylation]
GO:0008270 [zinc ion binding]
GO:0022409 [positive regulation of cell-cell adhesion]
GO:0032794 [GTPase activating protein binding]
GO:0043547 [positive regulation of GTPase activity]
GO:0044822 [poly(A) RNA binding]
GO:0046777 [protein autophosphorylation]
GO:0050766 [positive regulation of phagocytosis]
GO:0072697 [protein localization to cell cortex]
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 569 aa
58.8 kDa 		No 0
MEX3B-002
ENSP00000456938
ENST00000558133
Q6ZN04 [Direct mapping]
RNA-binding protein MEX3B
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Predicted intracellular proteins
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GO:0000932 [cytoplasmic mRNA processing body]
GO:0005509 [calcium ion binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006468 [protein phosphorylation]
GO:0008270 [zinc ion binding]
GO:0044822 [poly(A) RNA binding]
GO:0046777 [protein autophosphorylation]
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 158 aa
16.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.