Expression of FAM46C in cancer - Summary - The Human Protein Atlas

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FAM46C

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	FAM46C
Gene description	Family with sequence similarity 46, member C
Protein class	Cancer-related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (Karpas-707, RPMI-8226, U-266/70)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Membranous and/or cytoplasmic expression in selected tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA054049
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and endometrial cancer (favourable).
Renal cancer p<0.001 Endometrial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA054049

GENE INFORMATION
Gene name	FAM46C (HGNC Symbol)
Synonyms	FLJ20202
Description	Family with sequence similarity 46, member C (HGNC Symbol)
Entrez gene summary
Chromosome	1
Cytoband	p12
Chromosome location (bp)	117605934 - 117628372
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000183508 (version 83.38)
Entrez gene	54855
UniProt	Q5VWP2 (UniProt - Evidence at protein level)
neXtProt	NX_Q5VWP2
Antibodypedia	FAM46C antibodies

PROTEIN BROWSER

FAM46C-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FAM46C-001 ENSP00000358458 ENST00000369448	Q5VWP2 [Direct mapping] Protein FAM46C Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] Show all	391 aa 44.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.