Expression of COA5 in cancer - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	COA5
Gene description	Cytochrome c oxidase assembly factor 5
Protein class	Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues, most abundant in adrenal and parathyroid gland.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA057768
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PROGNOSTIC SUMMARY
Prognostic marker in urothelial cancer (favourable) and lung cancer (favourable).
Urothelial cancer p<0.001 Lung cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA057768

GENE INFORMATION
Gene name	COA5 (HGNC Symbol)
Synonyms	C2orf64, FLJ27524, MGC52110, Pet191
Description	Cytochrome c oxidase assembly factor 5 (HGNC Symbol)
Entrez gene summary	This gene encodes an ortholog of yeast Pet191, which in yeast is a subunit of a large oligomeric complex associated with the mitochondrial inner membrane, and required for the assembly of the cytochrome c oxidase complex. Mutations in this gene are associated with mitochondrial complex IV deficiency, a disorder of the mitochondrial respiratory chain with heterogeneous clinical manifestations, ranging from isolated myopathy to a severe disease affecting several tissues and organs. [provided by RefSeq, Dec 2011]
Chromosome	2
Cytoband	q11.2
Chromosome location (bp)	98599310 - 98608515
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000183513 (version 83.38)
Entrez gene	493753
UniProt	Q86WW8 (UniProt - Evidence at protein level)
neXtProt	NX_Q86WW8
Antibodypedia	COA5 antibodies

PROTEIN BROWSER

COA5-001	COA5-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
COA5-001 ENSP00000330730 ENST00000328709	Q86WW8 [Direct mapping] Cytochrome c oxidase assembly factor 5 Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005739 [mitochondrion] Show all	74 aa 8.4 kDa	No	0
COA5-002 ENSP00000386934 ENST00000409997	B9A057 [Direct mapping] Cytochrome c oxidase assembly factor 5 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005739 [mitochondrion] Show all	73 aa 8.1 kDa	No	0