Expression of ACSM5 in cancer - Summary - The Human Protein Atlas

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ACSM5

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ACSM5
Gene description	Acyl-CoA synthetase medium-chain family member 5
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Group enriched (liver cancer, renal cancer)
HPA (cell line):	Group enriched (ASC TERT1, U-87 MG)
HPA (normal tissue):	Tissue enhanced (liver)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in liver and kidney.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification. Presumed off target binding observed and disregarded.
Reliability score	Uncertain based on 1 antibody. HPA041435
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Group enriched (liver cancer, renal cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA041435

GENE INFORMATION
Gene name	ACSM5 (HGNC Symbol)
Synonyms	FLJ20581
Description	Acyl-CoA synthetase medium-chain family member 5 (HGNC Symbol)
Entrez gene summary
Chromosome	16
Cytoband	p12.3
Chromosome location (bp)	20409534 - 20441336
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000183549 (version 83.38)
Entrez gene	54988
UniProt	Q6NUN0 (UniProt - Evidence at protein level)
neXtProt	NX_Q6NUN0
Antibodypedia	ACSM5 antibodies

PROTEIN BROWSER

ACSM5-001	ACSM5-002	ACSM5-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ACSM5-001 ENSP00000327916 ENST00000331849	Q6NUN0 [Direct mapping] Acyl-coenzyme A synthetase ACSM5, mitochondrial Show all	Enzymes ENZYME proteins Ligase MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0005524 [ATP binding] GO:0005525 [GTP binding] GO:0005759 [mitochondrial matrix] GO:0006631 [fatty acid metabolic process] GO:0008152 [metabolic process] GO:0046872 [metal ion binding] GO:0047760 [butyrate-CoA ligase activity] Show all	579 aa 64.8 kDa	No	0
ACSM5-002 ENSP00000460112 ENST00000575584	Q6NUN0 [Direct mapping] Acyl-coenzyme A synthetase ACSM5, mitochondrial Show all	Enzymes ENZYME proteins Ligase MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0005524 [ATP binding] GO:0005525 [GTP binding] GO:0005759 [mitochondrial matrix] GO:0006631 [fatty acid metabolic process] GO:0008152 [metabolic process] GO:0046872 [metal ion binding] GO:0047760 [butyrate-CoA ligase activity] Show all	208 aa 23.3 kDa	No	0
ACSM5-003 ENSP00000478073 ENST00000575070	A0A087WTR4 [Direct mapping] Acyl-coenzyme A synthetase ACSM5, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		74 aa 8.5 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.