Expression of PCBP3 in cancer - Summary - The Human Protein Atlas

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PCBP3

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	PCBP3
Gene description	Poly(rC) binding protein 3
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (HDLM-2, SH-SY5Y, U-87 MG, U-937)
HPA (normal tissue):	Tissue enhanced (testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA030247
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA030247

GENE INFORMATION
Gene name	PCBP3
Synonyms
Description	Poly(rC) binding protein 3 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the KH-domain protein subfamily. Proteins of this subfamily, also referred to as alpha-CPs, bind to RNA with a specificity for C-rich pyrimidine regions. Alpha-CPs play important roles in post-transcriptional activities and have different cellular distributions. This gene's protein is found in the cytoplasm, yet it lacks the nuclear localization signals found in other subfamily members. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
Chromosome	21
Cytoband	q22.3
Chromosome location (bp)	45643694 - 45942454
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000183570 (version 83.38)
Entrez gene	54039
UniProt	P57721 (UniProt - Evidence at transcript level)
neXtProt	NX_P57721
Antibodypedia	PCBP3 antibodies

PROTEIN BROWSER

PCBP3-001	PCBP3-002	PCBP3-003	PCBP3-004	PCBP3-005	PCBP3-009	PCBP3-013	PCBP3-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PCBP3-001 ENSP00000383168 ENST00000400314	P57721 [Direct mapping] Poly(rC)-binding protein 3 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0003677 [DNA binding] GO:0003723 [RNA binding] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0016071 [mRNA metabolic process] GO:0030529 [ribonucleoprotein complex] GO:0044822 [poly(A) RNA binding] GO:0070062 [extracellular exosome] Show all	371 aa 39.5 kDa	No	0
PCBP3-002 ENSP00000383165 ENST00000400310	P57721 [Direct mapping] Poly(rC)-binding protein 3 Show all	Predicted intracellular proteins Plasma proteins Show all	GO:0003676 [nucleic acid binding] GO:0003677 [DNA binding] GO:0003723 [RNA binding] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0016071 [mRNA metabolic process] GO:0030529 [ribonucleoprotein complex] GO:0044822 [poly(A) RNA binding] GO:0070062 [extracellular exosome] Show all	351 aa 37.3 kDa	No	0
PCBP3-003 ENSP00000383159 ENST00000400304	E9PFP8 [Direct mapping] Poly(rC)-binding protein 3 Show all	Predicted intracellular proteins Show all	GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] Show all	361 aa 38.2 kDa	No	0
PCBP3-004 ENSP00000383164 ENST00000400309	P57721 [Direct mapping] Poly(rC)-binding protein 3 Show all	Predicted intracellular proteins Plasma proteins Show all	GO:0003676 [nucleic acid binding] GO:0003677 [DNA binding] GO:0003723 [RNA binding] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0016071 [mRNA metabolic process] GO:0030529 [ribonucleoprotein complex] GO:0044822 [poly(A) RNA binding] GO:0070062 [extracellular exosome] Show all	370 aa 39.3 kDa	No	0
PCBP3-005 ENSP00000383163 ENST00000400308	P57721 [Direct mapping] Poly(rC)-binding protein 3 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0003677 [DNA binding] GO:0003723 [RNA binding] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0016071 [mRNA metabolic process] GO:0030529 [ribonucleoprotein complex] GO:0044822 [poly(A) RNA binding] GO:0070062 [extracellular exosome] Show all	345 aa 36.8 kDa	No	0
PCBP3-009 ENSP00000383160 ENST00000400305	J3QT27 [Direct mapping] Poly(rC)-binding protein 3 Show all	Predicted intracellular proteins Show all	GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] Show all	322 aa 34.4 kDa	No	0
PCBP3-013 ENSP00000448986 ENST00000549265		Predicted intracellular proteins Show all		5 aa 0.6 kDa	No	0
PCBP3-201 ENSP00000401198 ENST00000449640	E9PFP8 [Direct mapping] Poly(rC)-binding protein 3 Show all	Predicted intracellular proteins Show all	GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] Show all	361 aa 38.2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.