Expression of TANGO2 in cancer - Summary - The Human Protein Atlas

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TANGO2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	TANGO2
Gene description	Transport and golgi organization 2 homolog
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	12
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA003080
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (favourable).
Pancreatic cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA003080

GENE INFORMATION
Gene name	TANGO2 (HGNC Symbol)
Synonyms	C22orf25, DKFZp761P1121
Description	Transport and golgi organization 2 homolog (HGNC Symbol)
Entrez gene summary
Chromosome	22
Cytoband	q11.21
Chromosome location (bp)	20017014 - 20065926
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000183597 (version 83.38)
Entrez gene	128989
UniProt	Q6ICL3 (UniProt - Evidence at transcript level)
neXtProt	NX_Q6ICL3
Antibodypedia	TANGO2 antibodies

PROTEIN BROWSER

TANGO2-001	TANGO2-003	TANGO2-005	TANGO2-006	TANGO2-007	TANGO2-011	TANGO2-014	TANGO2-201	TANGO2-202	TANGO2-203	TANGO2-204	TANGO2-205

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TANGO2-001 ENSP00000385662 ENST00000401886	Q6ICL3 [Direct mapping] Transport and Golgi organization protein 2 homolog Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		214 aa 24.2 kDa	No	0
TANGO2-003 ENSP00000332721 ENST00000327374	Q6ICL3 [Direct mapping] Transport and Golgi organization protein 2 homolog Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all		276 aa 30.9 kDa	No	0
TANGO2-005 ENSP00000384827 ENST00000401833	Q6ICL3 [Direct mapping] Transport and Golgi organization protein 2 homolog Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		317 aa 35 kDa	No	0
TANGO2-006 ENSP00000413850 ENST00000432198	C9JKN2 [Direct mapping] Transport and Golgi organization protein 2 homolog Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		88 aa 10.1 kDa	No	0
TANGO2-007 ENSP00000381122 ENST00000398042	Q6ICL3 [Direct mapping] Transport and Golgi organization protein 2 homolog Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		214 aa 24.2 kDa	No	0
TANGO2-011 ENSP00000415450 ENST00000450664	C9JDT9 [Direct mapping] Transport and Golgi organization protein 2 homolog Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		165 aa 18.5 kDa	No	0
TANGO2-014 ENSP00000411602 ENST00000434168	C9J695 [Direct mapping] Transport and Golgi organization protein 2 homolog Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		226 aa 25.2 kDa	No	0
TANGO2-201 ENSP00000396182 ENST00000420290	B7Z4A5 [Direct mapping] Transport and Golgi organization protein 2 homolog; cDNA FLJ50572, moderately similar to Ser/Thr-rich protein T10 in DGCR region Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		107 aa 12 kDa	No	0
TANGO2-202 ENSP00000402926 ENST00000432883	Q6ICL3 [Direct mapping] Transport and Golgi organization protein 2 homolog Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		178 aa 19.5 kDa	No	0
TANGO2-203 ENSP00000391262 ENST00000434570	Q6ICL3 [Direct mapping] Transport and Golgi organization protein 2 homolog Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		198 aa 21.6 kDa	No	0
TANGO2-204 ENSP00000389797 ENST00000447208	A0A0A0MSI5 [Direct mapping] Transport and Golgi organization protein 2 homolog Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		201 aa 22.8 kDa	No	0
TANGO2-205 ENSP00000403645 ENST00000456048	Q6ICL3 [Direct mapping] Transport and Golgi organization protein 2 homolog Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005739 [mitochondrion] Show all	317 aa 35 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.