Expression of GKN2 in cancer - Summary - The Human Protein Atlas

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GKN2

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	GKN2
Gene description	Gastrokine 2
Protein class	Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (stomach cancer)
HPA (cell line):	Cell line enhanced (A549, HMC-1, NTERA-2, PC-3, U-2 OS)
HPA (normal tissue):	Tissue enriched (stomach)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in gastric mucosa.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.
Reliability score	Supported based on 1 antibody. HPA057765
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (stomach cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA057765

GENE INFORMATION
Gene name	GKN2 (HGNC Symbol)
Synonyms	blottin, BRICD1B, GDDR, PRO813, TFIZ1, VLTI465
Description	Gastrokine 2 (HGNC Symbol)
Entrez gene summary	The secretory protein encoded by this gene is produced in gastric surface mucous cells, where it can bind trefoil factor family peptide 1 or gastrokine-1. This gene may be a tumor suppressor gene, as its expression is markedly decreased in gastric cancer tissues. The encoded protein interacts with gastrokine-1 and regulates homeostasis of the gastric mucosa. [provided by RefSeq, Dec 2015]
Chromosome	2
Cytoband	p13.3
Chromosome location (bp)	68945232 - 68952970
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000183607 (version 83.38)
Entrez gene	200504
UniProt	Q86XP6 (UniProt - Evidence at protein level)
neXtProt	NX_Q86XP6
Antibodypedia	GKN2 antibodies

PROTEIN BROWSER

GKN2-001	GKN2-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GKN2-001 ENSP00000329292 ENST00000328895	Q86XP6 [Direct mapping] Gastrokine-2 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005576 [extracellular region] GO:0045178 [basal part of cell] Show all	184 aa 20.5 kDa	Yes	0
GKN2-003 ENSP00000428538 ENST00000481498	E5RHQ8 [Direct mapping] Gastrokine-2 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		161 aa 18.5 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.