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CCR3

GENERAL INFORMATION

Gene name

 CCR3

Gene description

 Chemokine (C-C motif) receptor 3

Protein class

 CD markers
G-protein coupled receptors
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Not detected
HPA (cell line):Cell line enriched (RPMI-8226)
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Mainly membrane expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Uncertain based on 1 antibody.
CAB003795
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Not detected

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
CAB003795

GENE INFORMATION

Gene name

 CCR3 (HGNC Symbol)

Synonyms

 CC-CKR-3, CD193, CKR3, CMKBR3

Description

 Chemokine (C-C motif) receptor 3 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a receptor for C-C type chemokines. It belongs to family 1 of the G protein-coupled receptors. This receptor binds and responds to a variety of chemokines, including eotaxin (CCL11), eotaxin-3 (CCL26), MCP-3 (CCL7), MCP-4 (CCL13), and RANTES (CCL5). It is highly expressed in eosinophils and basophils, and is also detected in TH1 and TH2 cells, as well as in airway epithelial cells. This receptor may contribute to the accumulation and activation of eosinophils and other inflammatory cells in the allergic airway. It is also known to be an entry co-receptor for HIV-1. This gene and seven other chemokine receptor genes form a chemokine receptor gene cluster on the chromosomal region 3p21. Alternatively spliced transcript variants have been described. [provided by RefSeq, Sep 2009]

Chromosome

 3

Cytoband

 p21.31

Chromosome location (bp)

 46163604 - 46266706

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000183625 (version 83.38)

Entrez gene

 1232

UniProt

 P51677 (UniProt - Evidence at protein level)

neXtProt

 NX_P51677

Antibodypedia

 CCR3 antibodies

PROTEIN BROWSER
CCR3-001
CCR3-002
CCR3-003
CCR3-004
CCR3-007
CCR3-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CCR3-001
ENSP00000350003
ENST00000357422
P51677 [Direct mapping]
C-C chemokine receptor type 3
A0A024R2Z3 [Target identity:100%; Query identity:100%]
Chemokine (C-C motif) receptor 3, isoform CRA_a
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CD markers
G-protein coupled receptors
   GPCRs excl olfactory receptors
   Chemokines and chemotactic factors receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
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GO:0004930 [G-protein coupled receptor activity]
GO:0004950 [chemokine receptor activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006954 [inflammatory response]
GO:0006968 [cellular defense response]
GO:0007155 [cell adhesion]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007188 [adenylate cyclase-modulating G-protein coupled receptor signaling pathway]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0016021 [integral component of membrane]
GO:0016032 [viral process]
GO:0045766 [positive regulation of angiogenesis]
GO:0070098 [chemokine-mediated signaling pathway]
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 355 aa
41 kDa 		No 7
CCR3-002
ENSP00000379271
ENST00000395940
P51677 [Direct mapping]
C-C chemokine receptor type 3
A0A024R2Z3 [Target identity:100%; Query identity:100%]
Chemokine (C-C motif) receptor 3, isoform CRA_a
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CD markers
G-protein coupled receptors
   GPCRs excl olfactory receptors
   Chemokines and chemotactic factors receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Show all
GO:0004930 [G-protein coupled receptor activity]
GO:0004950 [chemokine receptor activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006954 [inflammatory response]
GO:0006968 [cellular defense response]
GO:0007155 [cell adhesion]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007188 [adenylate cyclase-modulating G-protein coupled receptor signaling pathway]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0016021 [integral component of membrane]
GO:0016032 [viral process]
GO:0045766 [positive regulation of angiogenesis]
GO:0070098 [chemokine-mediated signaling pathway]
Show all
 355 aa
41 kDa 		No 7
CCR3-003
ENSP00000389336
ENST00000452454
Q8TDP5 [Direct mapping]
C-C chemokine receptor type 3; CC chemokine receptor 3
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
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GO:0004930 [G-protein coupled receptor activity]
GO:0004950 [chemokine receptor activity]
GO:0006935 [chemotaxis]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0016021 [integral component of membrane]
GO:0070098 [chemokine-mediated signaling pathway]
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 80 aa
9 kDa 		No 1
CCR3-004
ENSP00000401822
ENST00000457243
Q8TDP4 [Direct mapping]
C-C chemokine receptor type 3; CC chemokine receptor 3
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Predicted intracellular proteins
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 21 aa
2.3 kDa 		No 0
CCR3-007
ENSP00000379273
ENST00000395942
P51677 [Direct mapping]
C-C chemokine receptor type 3
A0A024R2Z3 [Target identity:100%; Query identity:100%]
Chemokine (C-C motif) receptor 3, isoform CRA_a
Show all
CD markers
G-protein coupled receptors
   GPCRs excl olfactory receptors
   Chemokines and chemotactic factors receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Show all
GO:0004930 [G-protein coupled receptor activity]
GO:0004950 [chemokine receptor activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006954 [inflammatory response]
GO:0006968 [cellular defense response]
GO:0007155 [cell adhesion]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007188 [adenylate cyclase-modulating G-protein coupled receptor signaling pathway]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0016021 [integral component of membrane]
GO:0016032 [viral process]
GO:0045766 [positive regulation of angiogenesis]
GO:0070098 [chemokine-mediated signaling pathway]
Show all
 355 aa
41 kDa 		No 7
CCR3-201
ENSP00000441600
ENST00000545097
P51677 [Direct mapping]
C-C chemokine receptor type 3
Show all
CD markers
G-protein coupled receptors
   GPCRs excl olfactory receptors
   Chemokines and chemotactic factors receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Show all
GO:0001938 [positive regulation of endothelial cell proliferation]
GO:0004930 [G-protein coupled receptor activity]
GO:0004950 [chemokine receptor activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006935 [chemotaxis]
GO:0006954 [inflammatory response]
GO:0006968 [cellular defense response]
GO:0007155 [cell adhesion]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007188 [adenylate cyclase-modulating G-protein coupled receptor signaling pathway]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0016021 [integral component of membrane]
GO:0016032 [viral process]
GO:0016493 [C-C chemokine receptor activity]
GO:0045766 [positive regulation of angiogenesis]
GO:0070098 [chemokine-mediated signaling pathway]
Show all
 376 aa
43.5 kDa 		No 7

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.