Tissue expression of MARCH11 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	MARCH11
Gene description	Membrane-associated ring finger (C3HC4) 11
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enriched (testis)
GTEx:	Tissue enriched (testis)
FANTOM5:	Group enriched (pituitary gland, testis)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (testis)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (testis)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Group enriched (pituitary gland, testis)

GENE INFORMATION
Gene name	MARCH11 (HGNC Symbol)
Synonyms	MARCH-XI
Description	Membrane-associated ring finger (C3HC4) 11 (HGNC Symbol)
Entrez gene summary	MARCH11 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). These enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their intracellular transport. March11 appears to have a role in ubiquitin-mediated protein sorting in the trans-Golgi network (TGN)-multivesicular body (MVB) transport pathway (Morokuma et al., 2007 [PubMed 17604280]).[supplied by OMIM, Apr 2010]
Chromosome	5
Cytoband	p15.1
Chromosome location (bp)	16067139 - 16180762
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000183654 (version 83.38)
Entrez gene	441061
UniProt	A6NNE9 (UniProt - Evidence at transcript level)
neXtProt	NX_A6NNE9
Antibodypedia	MARCH11 antibodies

PROTEIN BROWSER

MARCH11-001	MARCH11-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MARCH11-001 ENSP00000333181 ENST00000332432	A6NNE9 [Direct mapping] E3 ubiquitin-protein ligase MARCH11 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0008270 [zinc ion binding] GO:0016021 [integral component of membrane] GO:0016567 [protein ubiquitination] GO:0016874 [ligase activity] GO:0030659 [cytoplasmic vesicle membrane] Show all	402 aa 43.9 kDa	No	2
MARCH11-002 ENSP00000424425 ENST00000507111	H0Y9K6 [Direct mapping] E3 ubiquitin-protein ligase MARCH11 Show all	Predicted intracellular proteins Show all		54 aa 6.2 kDa	No	0