Expression of PSG9 in cancer - Summary - The Human Protein Atlas

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PSG9

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	PSG9
Gene description	Pregnancy specific beta-1-glycoprotein 9
Protein class	Plasma proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Not detected
HPA (cell line):	Cell line enhanced (BJ, BJ hTERT+ SV40 Large T+, HBF TERT88, T-47d, U-2197)
HPA (normal tissue):	Tissue enriched (placenta)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in trophoblasts.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Caution, targets protein from more than one gene. Presumed off target binding observed and disregarded.
Reliability score	Approved based on 1 antibody. HPA046327
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Not detected

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA046327

GENE INFORMATION
Gene name	PSG9 (HGNC Symbol)
Synonyms	PSG11, PSGII
Description	Pregnancy specific beta-1-glycoprotein 9 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the pregnancy-specific glycoprotein (PSG) family. This protein family and the closely related carcinoembryonic antigen cell adhesion molecule (CEACAM) gene family are both members of the immunoglobulin superfamily, and are organized as a large gene cluster. This protein is thought to inhibit platelet-fibrinogen interactions. Several studies suggest that reduced serum concentrations of PSGs are associated with fetal growth restrictions, while up-regulation of this gene has been observed in colorectal cancers. Several pseudogenes of this gene are found on chromosome 19. Alternative splicing results in multiple transcript variants that encode multiple protein isoforms. [provided by RefSeq, Sep 2014]
Chromosome	19
Cytoband	q13.31
Chromosome location (bp)	43211791 - 43269530
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000183668 (version 83.38)
Entrez gene	5678
UniProt	Q00887 (UniProt - Evidence at transcript level)
neXtProt	NX_Q00887
Antibodypedia	PSG9 antibodies

PROTEIN BROWSER

PSG9-001	PSG9-002	PSG9-006	PSG9-007	PSG9-008	PSG9-009	PSG9-011	PSG9-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PSG9-001 ENSP00000270077 ENST00000270077	Q00887 [Direct mapping] Pregnancy-specific beta-1-glycoprotein 9 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0007565 [female pregnancy] Show all	426 aa 48.3 kDa	Yes	0
PSG9-002 ENSP00000244293 ENST00000244293	Q00887 [Direct mapping] Pregnancy-specific beta-1-glycoprotein 9 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0007565 [female pregnancy] Show all	402 aa 45.3 kDa	Yes	1
PSG9-006 ENSP00000471174 ENST00000596730	M0R0E4 [Direct mapping] Pregnancy-specific beta-1-glycoprotein 9 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	309 aa 34.8 kDa	Yes	1
PSG9-007 ENSP00000396753 ENST00000443718	E7EW65 [Direct mapping] Pregnancy-specific beta-1-glycoprotein 9 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	333 aa 37.7 kDa	Yes	0
PSG9-008 ENSP00000471453 ENST00000593948	M0R0U8 [Direct mapping] Pregnancy specific beta-1-glycoprotein 9, isoform CRA_c; Pregnancy-specific beta-1-glycoprotein 9 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	333 aa 37.6 kDa	Yes	0
PSG9-009 ENSP00000291752 ENST00000291752	G3XAA7 [Direct mapping] Pregnancy specific beta-1-glycoprotein 9, isoform CRA_d; Pregnancy-specific beta-1-glycoprotein 9 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	240 aa 27.1 kDa	Yes	0
PSG9-011 ENSP00000400484 ENST00000418820	H7C1I4 [Direct mapping] Pregnancy-specific beta-1-glycoprotein 9 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	326 aa 37.1 kDa	Yes	0
PSG9-201 ENSP00000481887 ENST00000621109	A0A087WYK1 [Direct mapping] Pregnancy-specific beta-1-glycoprotein 9 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	419 aa 47.7 kDa	Yes	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.