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BMP8A

GENERAL INFORMATION

Gene name

 BMP8A

Gene description

 Bone morphogenetic protein 8a

Protein class

 Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (U-2197, U-266/70, U-266/84)
HPA (normal tissue):Tissue enriched (thyroid gland)

Protein evidence

 Evidence at transcript level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 BMP8A

Synonyms

Description

 Bone morphogenetic protein 8a (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the transforming growth factor beta superfamily of regulatory proteins. The encoded preproprotein undergoes proteolytic processing to generate the mature protein. Studies in laboratory mice suggest that this protein may play a role in development of the reproductive system. This gene may have arose from a gene duplication event and its gene duplicate is also present on chromosome 1. [provided by RefSeq, Nov 2015]

Chromosome

 1

Cytoband

 p34.3

Chromosome location (bp)

 39491646 - 39525935

Protein evidence

 Evidence at transcript level (all genes)

Ensembl

 ENSG00000183682 (version 83.38)

Entrez gene

 353500

UniProt

 Q7Z5Y6 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q7Z5Y6

Antibodypedia

 BMP8A antibodies

PROTEIN BROWSER
BMP8A-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
BMP8A-001
ENSP00000327440
ENST00000331593
Q7Z5Y6 [Direct mapping]
Bone morphogenetic protein 8A
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
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GO:0001503 [ossification]
GO:0002024 [diet induced thermogenesis]
GO:0005125 [cytokine activity]
GO:0005160 [transforming growth factor beta receptor binding]
GO:0005615 [extracellular space]
GO:0008083 [growth factor activity]
GO:0010862 [positive regulation of pathway-restricted SMAD protein phosphorylation]
GO:0030509 [BMP signaling pathway]
GO:0040007 [growth]
GO:0042981 [regulation of apoptotic process]
GO:0043408 [regulation of MAPK cascade]
GO:0046676 [negative regulation of insulin secretion]
GO:0048468 [cell development]
GO:0051216 [cartilage development]
GO:0060395 [SMAD protein signal transduction]
GO:0070700 [BMP receptor binding]
GO:2000505 [regulation of energy homeostasis]
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 402 aa
44.8 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.