We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
Strong cytoplasmic and membranous staining was observed in a case of stomach cancer. A rare case of pancreatic cancer was moderately positive. Moderate nuclear staining was observed in occasional cases of testicular cancers. Remaining cancer tissues were negative.
GENE INFORMATION
Gene name
UPP1 (HGNC Symbol)
Synonyms
UDRPASE, UP, UPASE, UPP
Description
Uridine phosphorylase 1 (HGNC Symbol)
Entrez gene summary
The 2 known types of pyrimidine nucleoside phosphorylases, uridine phosphorylase (UP; EC 2.4.2.3) and thymidine phosphorylase (TP; EC 2.4.2.4), in the presence of orthophosphate, catalyze the reversible phosphorolysis of uridine and thymidine or deoxyuridine, respectively, to free bases and ribose-1-phosphate or deoxyribose-1-phosphate. Pyrimidine nucleoside phosphorylases can add ribose or deoxyribose to pyrimidine bases to form nucleosides that can be incorporated into RNA or DNA (Watanabe and Uchida, 1995 [PubMed 7488099]).[supplied by OMIM, Aug 2009]
Enzymes ENZYME proteins Transferases SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)