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ASCL2

GENERAL INFORMATION

Gene name

 ASCL2

Gene description

 Achaete-scute family bHLH transcription factor 2

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Group enriched (colorectal cancer, stomach cancer)
HPA (cell line):Group enriched (BEWO, NB-4, SCLC-21H)
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (favourable) and cervical cancer (favourable).
Pancreatic cancer p<0.001
Cervical cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Group enriched (colorectal cancer, stomach cancer)

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 ASCL2 (HGNC Symbol)

Synonyms

 ASH2, bHLHa45, HASH2

Description

 Achaete-scute family bHLH transcription factor 2 (HGNC Symbol)

Entrez gene summary

 This gene is a member of the basic helix-loop-helix (BHLH) family of transcription factors. It activates transcription by binding to the E box (5'-CANNTG-3'). Dimerization with other BHLH proteins is required for efficient DNA binding. Involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system. [provided by RefSeq, Jul 2008]

Chromosome

 11

Cytoband

 p15.5

Chromosome location (bp)

 2268495 - 2270952

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000183734 (version 83.38)

Entrez gene

 430

UniProt

 Q99929 (UniProt - Evidence at protein level)

neXtProt

 NX_Q99929

Antibodypedia

 ASCL2 antibodies

PROTEIN BROWSER
ASCL2-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ASCL2-001
ENSP00000332293
ENST00000331289
Q99929 [Direct mapping]
Achaete-scute homolog 2
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Predicted intracellular proteins
Transcription factors
   Basic domains
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001666 [response to hypoxia]
GO:0001701 [in utero embryonic development]
GO:0001890 [placenta development]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0010626 [negative regulation of Schwann cell proliferation]
GO:0030154 [cell differentiation]
GO:0035019 [somatic stem cell population maintenance]
GO:0043565 [sequence-specific DNA binding]
GO:0046983 [protein dimerization activity]
GO:0060708 [spongiotrophoblast differentiation]
GO:0060712 [spongiotrophoblast layer development]
GO:0070888 [E-box binding]
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 193 aa
20.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.