Cell atlas - KREMEN1 - The Human Protein Atlas

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KREMEN1

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nuclear bodies
	Nucleoplasm

Human cell
	Cytosol
	Nucleoplasm

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GENERAL INFORMATION
Gene name	KREMEN1
Gene description	Kringle containing transmembrane protein 1
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoplasm. In addition localized to the cytosol & nuclear bodies.
RNA cell category	Cell line enhanced (U-2197)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved)
Additional location	In addition localized to the Nuclear bodies (approved), Cytosol (approved)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA058513
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (U-2197) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoplasm. In addition localized to the cytosol & nuclear bodies.

Main location

Nucleoplasm (approved)

Additional location

Nuclear bodies (approved), Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA058513	HEK 293	Nucleoplasm	Intensity
			Nuclear bodies	Intensity
			Cytosol
	HPA058513	RH-30	Nucleoplasm
			Nuclear bodies
			Cytosol
	HPA058513	U-2 OS	Nucleoplasm	Intensity
			Nuclear bodies	Intensity
			Cytosol

GENE INFORMATION
Gene name	KREMEN1 (HGNC Symbol)
Synonyms	KREMEN, KRM1
Description	Kringle containing transmembrane protein 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor that functionally cooperates with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein is a component of a membrane complex that modulates canonical WNT signaling through lipoprotein receptor-related protein 6 (LRP6). It contains extracellular kringle, WSC, and CUB domains. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene. [provided by RefSeq, Jul 2008]
Chromosome	22
Cytoband	q12.1
Chromosome location (bp)	29073078 - 29168333
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000183762 (version 83.38)
Entrez gene	83999
UniProt	Q96MU8 (UniProt - Evidence at transcript level)
neXtProt	NX_Q96MU8
Antibodypedia	KREMEN1 antibodies

PROTEIN BROWSER

KREMEN1-002	KREMEN1-003	KREMEN1-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KREMEN1-002 ENSP00000331242 ENST00000327813	Q96MU8 [Direct mapping] Kremen protein 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0007154 [cell communication] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016055 [Wnt signaling pathway] GO:0060828 [regulation of canonical Wnt signaling pathway] Show all	492 aa 53.8 kDa	Yes	1
KREMEN1-003 ENSP00000383189 ENST00000400335	Q96MU8 [Direct mapping] Kremen protein 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0007154 [cell communication] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016055 [Wnt signaling pathway] GO:0060828 [regulation of canonical Wnt signaling pathway] Show all	458 aa 50.2 kDa	Yes	1
KREMEN1-004 ENSP00000385431 ENST00000407188	Q96MU8 [Direct mapping] Kremen protein 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0007154 [cell communication] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016055 [Wnt signaling pathway] GO:0060828 [regulation of canonical Wnt signaling pathway] Show all	473 aa 51.7 kDa	Yes	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.