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CHEK2

GENERAL INFORMATION

Gene name

 CHEK2

Gene description

 Checkpoint kinase 2

Protein class

 Cancer-related genes
Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Membrane,Secreted

Number of transcripts

 15
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Nuclear expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA001878 , CAB002030
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Testis cancer

STAINING SUMMARY
HPA001878
CAB002030

GENE INFORMATION

Gene name

 CHEK2 (HGNC Symbol)

Synonyms

 bA444G7, CDS1, CHK2, HuCds1, PP1425, RAD53

Description

 Checkpoint kinase 2 (HGNC Symbol)

Entrez gene summary

 In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53. Also, mutations in this gene are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors. This nuclear protein is a member of the CDS1 subfamily of serine/threonine protein kinases. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]

Chromosome

 22

Cytoband

 q12.1

Chromosome location (bp)

 28687743 - 28742422

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000183765 (version 83.38)

Entrez gene

 11200

UniProt

 O96017 (UniProt - Evidence at protein level)

neXtProt

 NX_O96017

Antibodypedia

 CHEK2 antibodies

PROTEIN BROWSER
«
CHEK2-002
CHEK2-003
CHEK2-005
CHEK2-006
CHEK2-010
CHEK2-011
CHEK2-012
CHEK2-013
CHEK2-017
CHEK2-018
CHEK2-019
CHEK2-021
CHEK2-022
CHEK2-201
CHEK2-202
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CHEK2-002
ENSP00000329178
ENST00000328354
O96017 [Direct mapping]
Serine/threonine-protein kinase Chk2
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CAMK Ser/Thr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000077 [DNA damage checkpoint]
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000781 [chromosome, telomeric region]
GO:0001302 [replicative cell aging]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005794 [Golgi apparatus]
GO:0006281 [DNA repair]
GO:0006302 [double-strand break repair]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006468 [protein phosphorylation]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0006975 [DNA damage induced protein phosphorylation]
GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage]
GO:0016605 [PML body]
GO:0019901 [protein kinase binding]
GO:0031625 [ubiquitin protein ligase binding]
GO:0042176 [regulation of protein catabolic process]
GO:0042770 [signal transduction in response to DNA damage]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0044257 [cellular protein catabolic process]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046777 [protein autophosphorylation]
GO:0046872 [metal ion binding]
GO:0050821 [protein stabilization]
GO:0051301 [cell division]
GO:0072428 [signal transduction involved in intra-S DNA damage checkpoint]
GO:0090307 [mitotic spindle assembly]
GO:0090399 [replicative senescence]
Show all
 543 aa
60.9 kDa 		No 1
CHEK2-003
ENSP00000372023
ENST00000382580
O96017 [Direct mapping]
Serine/threonine-protein kinase Chk2
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CAMK Ser/Thr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000077 [DNA damage checkpoint]
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000781 [chromosome, telomeric region]
GO:0001302 [replicative cell aging]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005794 [Golgi apparatus]
GO:0006281 [DNA repair]
GO:0006302 [double-strand break repair]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0006975 [DNA damage induced protein phosphorylation]
GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage]
GO:0010332 [response to gamma radiation]
GO:0016301 [kinase activity]
GO:0016605 [PML body]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0019901 [protein kinase binding]
GO:0031625 [ubiquitin protein ligase binding]
GO:0035690 [cellular response to drug]
GO:0042176 [regulation of protein catabolic process]
GO:0042770 [signal transduction in response to DNA damage]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0044257 [cellular protein catabolic process]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046777 [protein autophosphorylation]
GO:0046872 [metal ion binding]
GO:0050821 [protein stabilization]
GO:0051301 [cell division]
GO:0071157 [negative regulation of cell cycle arrest]
GO:0072428 [signal transduction involved in intra-S DNA damage checkpoint]
GO:0090307 [mitotic spindle assembly]
GO:0090399 [replicative senescence]
GO:1902520 [response to doxorubicin]
GO:1903926 [cellular response to bisphenol A]
GO:2000002 [negative regulation of DNA damage checkpoint]
GO:2000210 [positive regulation of anoikis]
Show all
 586 aa
65.4 kDa 		No 1
CHEK2-005
ENSP00000386087
ENST00000405598
O96017 [Direct mapping]
Serine/threonine-protein kinase Chk2
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CAMK Ser/Thr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000077 [DNA damage checkpoint]
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000781 [chromosome, telomeric region]
GO:0001302 [replicative cell aging]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005794 [Golgi apparatus]
GO:0006281 [DNA repair]
GO:0006302 [double-strand break repair]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006468 [protein phosphorylation]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0006975 [DNA damage induced protein phosphorylation]
GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage]
GO:0016605 [PML body]
GO:0019901 [protein kinase binding]
GO:0031625 [ubiquitin protein ligase binding]
GO:0042176 [regulation of protein catabolic process]
GO:0042770 [signal transduction in response to DNA damage]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0044257 [cellular protein catabolic process]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046777 [protein autophosphorylation]
GO:0046872 [metal ion binding]
GO:0050821 [protein stabilization]
GO:0051301 [cell division]
GO:0072428 [signal transduction involved in intra-S DNA damage checkpoint]
GO:0090307 [mitotic spindle assembly]
GO:0090399 [replicative senescence]
Show all
 543 aa
60.9 kDa 		No 1
CHEK2-006
ENSP00000385747
ENST00000404276
O96017 [Direct mapping]
Serine/threonine-protein kinase Chk2
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CAMK Ser/Thr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000077 [DNA damage checkpoint]
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000781 [chromosome, telomeric region]
GO:0001302 [replicative cell aging]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005794 [Golgi apparatus]
GO:0006281 [DNA repair]
GO:0006302 [double-strand break repair]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006468 [protein phosphorylation]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0006975 [DNA damage induced protein phosphorylation]
GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage]
GO:0016605 [PML body]
GO:0019901 [protein kinase binding]
GO:0031625 [ubiquitin protein ligase binding]
GO:0042176 [regulation of protein catabolic process]
GO:0042770 [signal transduction in response to DNA damage]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0044257 [cellular protein catabolic process]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046777 [protein autophosphorylation]
GO:0046872 [metal ion binding]
GO:0050821 [protein stabilization]
GO:0051301 [cell division]
GO:0072428 [signal transduction involved in intra-S DNA damage checkpoint]
GO:0090307 [mitotic spindle assembly]
GO:0090399 [replicative senescence]
Show all
 543 aa
60.9 kDa 		No 1
CHEK2-010
ENSP00000397478
ENST00000447421
B7ZBF6 [Direct mapping]
Serine/threonine-protein kinase Chk2
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005794 [Golgi apparatus]
GO:0006468 [protein phosphorylation]
Show all
 298 aa
33.9 kDa 		No 0
CHEK2-011
ENSP00000390244
ENST00000425190
B7ZBF2 [Direct mapping]
Serine/threonine-protein kinase Chk2
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
 121 aa
13.7 kDa 		No 0
CHEK2-012
ENSP00000381099
ENST00000398017
B7ZBF8 [Direct mapping]
Serine/threonine-protein kinase Chk2
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005794 [Golgi apparatus]
Show all
 172 aa
19.3 kDa 		Yes 0
CHEK2-013
ENSP00000408065
ENST00000439200
B7ZBF7 [Direct mapping]
Serine/threonine-protein kinase Chk2
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005794 [Golgi apparatus]
GO:0006468 [protein phosphorylation]
Show all
 295 aa
32.5 kDa 		No 0
CHEK2-017
ENSP00000483777
ENST00000464581
A0A087X102 [Direct mapping]
Serine/threonine-protein kinase Chk2
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
 137 aa
15.7 kDa 		No 0
CHEK2-018
ENSP00000416721
ENST00000434810
H0Y820 [Direct mapping]
Serine/threonine-protein kinase Chk2
Show all
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
 276 aa
31.1 kDa 		No 0
CHEK2-019
ENSP00000394430
ENST00000456369
H0Y4V6 [Direct mapping]
Serine/threonine-protein kinase Chk2
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
 144 aa
16.2 kDa 		No 0
CHEK2-021
ENSP00000384919
ENST00000403642
O96017 [Direct mapping]
Serine/threonine-protein kinase Chk2
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CAMK Ser/Thr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000077 [DNA damage checkpoint]
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000781 [chromosome, telomeric region]
GO:0001302 [replicative cell aging]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005794 [Golgi apparatus]
GO:0006281 [DNA repair]
GO:0006302 [double-strand break repair]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006468 [protein phosphorylation]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0006975 [DNA damage induced protein phosphorylation]
GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage]
GO:0016605 [PML body]
GO:0019901 [protein kinase binding]
GO:0031625 [ubiquitin protein ligase binding]
GO:0042176 [regulation of protein catabolic process]
GO:0042770 [signal transduction in response to DNA damage]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0044257 [cellular protein catabolic process]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046777 [protein autophosphorylation]
GO:0046872 [metal ion binding]
GO:0050821 [protein stabilization]
GO:0051301 [cell division]
GO:0072428 [signal transduction involved in intra-S DNA damage checkpoint]
GO:0090307 [mitotic spindle assembly]
GO:0090399 [replicative senescence]
Show all
 452 aa
50.2 kDa 		No 1
CHEK2-022
ENSP00000384835
ENST00000402731
O96017 [Direct mapping]
Serine/threonine-protein kinase Chk2
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CAMK Ser/Thr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000077 [DNA damage checkpoint]
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000781 [chromosome, telomeric region]
GO:0001302 [replicative cell aging]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005794 [Golgi apparatus]
GO:0006281 [DNA repair]
GO:0006302 [double-strand break repair]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006468 [protein phosphorylation]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0006975 [DNA damage induced protein phosphorylation]
GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage]
GO:0016605 [PML body]
GO:0019901 [protein kinase binding]
GO:0031625 [ubiquitin protein ligase binding]
GO:0042176 [regulation of protein catabolic process]
GO:0042770 [signal transduction in response to DNA damage]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0044257 [cellular protein catabolic process]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046777 [protein autophosphorylation]
GO:0046872 [metal ion binding]
GO:0050821 [protein stabilization]
GO:0051301 [cell division]
GO:0072428 [signal transduction involved in intra-S DNA damage checkpoint]
GO:0090307 [mitotic spindle assembly]
GO:0090399 [replicative senescence]
Show all
 514 aa
57.5 kDa 		No 1
CHEK2-201
ENSP00000329012
ENST00000348295
O96017 [Direct mapping]
Serine/threonine-protein kinase Chk2
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CAMK Ser/Thr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000077 [DNA damage checkpoint]
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000781 [chromosome, telomeric region]
GO:0001302 [replicative cell aging]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005794 [Golgi apparatus]
GO:0006281 [DNA repair]
GO:0006302 [double-strand break repair]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006468 [protein phosphorylation]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0006975 [DNA damage induced protein phosphorylation]
GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage]
GO:0016605 [PML body]
GO:0019901 [protein kinase binding]
GO:0031625 [ubiquitin protein ligase binding]
GO:0042176 [regulation of protein catabolic process]
GO:0042770 [signal transduction in response to DNA damage]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0044257 [cellular protein catabolic process]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046777 [protein autophosphorylation]
GO:0046872 [metal ion binding]
GO:0050821 [protein stabilization]
GO:0051301 [cell division]
GO:0072428 [signal transduction involved in intra-S DNA damage checkpoint]
GO:0090307 [mitotic spindle assembly]
GO:0090399 [replicative senescence]
Show all
 514 aa
57.5 kDa 		No 1
CHEK2-202
ENSP00000372006
ENST00000382565
C9JFD7 [Direct mapping]
Serine/threonine-protein kinase Chk2
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 207 aa
23.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.