Expression of KCTD16 in cancer - Summary - The Human Protein Atlas

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KCTD16

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	KCTD16
Gene description	Potassium channel tetramerization domain containing 16
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (renal cancer)
HPA (cell line):	Cell line enhanced (SCLC-21H, TIME)
HPA (normal tissue):	Group enriched (cerebral cortex, testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in CNS.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Presumed off target binding observed and disregarded.
Reliability score	Approved based on 2 antibodies. HPA044590 , HPA050154
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (renal cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA044590	HPA050154

GENE INFORMATION
Gene name	KCTD16 (HGNC Symbol)
Synonyms	KIAA1317
Description	Potassium channel tetramerization domain containing 16 (HGNC Symbol)
Entrez gene summary
Chromosome	5
Cytoband	q31.3
Chromosome location (bp)	144170832 - 144485686
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000183775 (version 83.38)
Entrez gene	57528
UniProt	Q68DU8 (UniProt - Evidence at protein level)
neXtProt	NX_Q68DU8
Antibodypedia	KCTD16 antibodies

PROTEIN BROWSER

KCTD16-001	KCTD16-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KCTD16-001 ENSP00000424151 ENST00000512467	Q68DU8 [Direct mapping] BTB/POZ domain-containing protein KCTD16 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0030054 [cell junction] GO:0042734 [presynaptic membrane] GO:0045211 [postsynaptic membrane] GO:0051260 [protein homooligomerization] Show all	428 aa 49.1 kDa	No	0
KCTD16-002 ENSP00000426548 ENST00000507359	Q68DU8 [Direct mapping] BTB/POZ domain-containing protein KCTD16 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0008277 [regulation of G-protein coupled receptor protein signaling pathway] GO:0030054 [cell junction] GO:0042734 [presynaptic membrane] GO:0043235 [receptor complex] GO:0045211 [postsynaptic membrane] GO:0051260 [protein homooligomerization] Show all	428 aa 49.1 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.