Expression of TUBA8 in cancer - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

TUBA8

TISSUE

premium

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	TUBA8
Gene description	Tubulin, alpha 8
Protein class	Disease related genes Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	5
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Not detected
HPA (cell line):	Group enriched (NB-4, SCLC-21H, TIME)
HPA (normal tissue):	Group enriched (cerebral cortex, heart muscle, skeletal muscle, testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Caution, targets protein from more than one gene.
Reliability score	Approved based on 3 antibodies. HPA043684 , HPA063394 , CAB046031
	SHOW MORE

PROGNOSTIC SUMMARY
Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Not detected

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA043684	HPA063394	CAB046031

GENE INFORMATION
Gene name	TUBA8 (HGNC Symbol)
Synonyms	TUBAL2
Description	Tubulin, alpha 8 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the alpha tubulin protein family. Alpha tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. Mutations in this gene are associated with polymicrogyria and optic nerve hypoplasia. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2010]
Chromosome	22
Cytoband	q11.21
Chromosome location (bp)	18110331 - 18146554
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000183785 (version 83.38)
Entrez gene	51807
UniProt	Q9NY65 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NY65
Antibodypedia	TUBA8 antibodies

PROTEIN BROWSER

TUBA8-001	TUBA8-002	TUBA8-003	TUBA8-004	TUBA8-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TUBA8-001 ENSP00000333326 ENST00000330423	Q9NY65 [Direct mapping] Tubulin alpha-8 chain Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003924 [GTPase activity] GO:0005200 [structural constituent of cytoskeleton] GO:0005525 [GTP binding] GO:0005737 [cytoplasm] GO:0005874 [microtubule] GO:0007017 [microtubule-based process] GO:0008152 [metabolic process] GO:0043234 [protein complex] GO:0051258 [protein polymerization] Show all	449 aa 50.1 kDa	No	0
TUBA8-002 ENSP00000318575 ENST00000316027	Q9NY65 [Direct mapping] Tubulin alpha-8 chain Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003924 [GTPase activity] GO:0005200 [structural constituent of cytoskeleton] GO:0005525 [GTP binding] GO:0005737 [cytoplasm] GO:0005874 [microtubule] GO:0007017 [microtubule-based process] GO:0008152 [metabolic process] GO:0043234 [protein complex] GO:0051258 [protein polymerization] Show all	383 aa 43 kDa	No	0
TUBA8-003 ENSP00000412646 ENST00000416740	C9J2C0 [Direct mapping] Tubulin alpha-8 chain Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003924 [GTPase activity] GO:0005200 [structural constituent of cytoskeleton] GO:0005525 [GTP binding] GO:0005874 [microtubule] GO:0007017 [microtubule-based process] GO:0008152 [metabolic process] GO:0043234 [protein complex] GO:0051258 [protein polymerization] Show all	467 aa 52 kDa	No	0
TUBA8-004 ENSP00000407624 ENST00000426208	C9K0S6 [Direct mapping] Tubulin alpha-8 chain Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003924 [GTPase activity] GO:0005525 [GTP binding] GO:0005874 [microtubule] GO:0007017 [microtubule-based process] GO:0008152 [metabolic process] Show all	47 aa 5.3 kDa	No	0
TUBA8-005 ENSP00000477306 ENST00000608634	V9GZ17 [Direct mapping] Tubulin alpha-8 chain Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0003924 [GTPase activity] GO:0005200 [structural constituent of cytoskeleton] GO:0005525 [GTP binding] GO:0005874 [microtubule] GO:0007017 [microtubule-based process] GO:0008152 [metabolic process] GO:0016021 [integral component of membrane] GO:0043234 [protein complex] GO:0051258 [protein polymerization] Show all	275 aa 31 kDa	No	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.