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CCR4

GENERAL INFORMATION

Gene name

 CCR4

Gene description

 Chemokine (C-C motif) receptor 4

Protein class

 CD markers
G-protein coupled receptors
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (appendix)
GTEx:Tissue enhanced (spleen)
FANTOM5:Tissue enhanced (lymph node, tonsil)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in several tissues, including lymphoid tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA031613
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (appendix)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (spleen)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (lymph node, tonsil)

GENE INFORMATION

Gene name

 CCR4 (HGNC Symbol)

Synonyms

 CC-CKR-4, CD194, ChemR13, CKR4, CMKBR4, k5-5

Description

 Chemokine (C-C motif) receptor 4 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene belongs to the G-protein-coupled receptor family . It is a receptor for the CC chemokine - MIP-1, RANTES, TARC and MCP-1. Chemokines are a group of small polypeptide, structurally related molecules that regulate cell trafficking of various types of leukocytes. The chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. [provided by RefSeq, Jul 2008]

Chromosome

 3

Cytoband

 p22.3

Chromosome location (bp)

 32951574 - 32956349

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000183813 (version 83.38)

Entrez gene

 1233

UniProt

 P51679 (UniProt - Evidence at protein level)

neXtProt

 NX_P51679

Antibodypedia

 CCR4 antibodies

PROTEIN BROWSER
CCR4-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CCR4-001
ENSP00000332659
ENST00000330953
P51679 [Direct mapping]
C-C chemokine receptor type 4
A0N0Q1 [Target identity:100%; Query identity:100%]
Chemokine (C-C motif) receptor 4; Chemokine (C-C motif) receptor 4, isoform CRA_a; cDNA FLJ75821, highly similar to Homo sapiens chemokine (C-C motif) receptor 4 (CCR4), mRNA
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CD markers
G-protein coupled receptors
   GPCRs excl olfactory receptors
   Chemokines and chemotactic factors receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
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GO:0001764 [neuron migration]
GO:0002507 [tolerance induction]
GO:0004930 [G-protein coupled receptor activity]
GO:0004950 [chemokine receptor activity]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006935 [chemotaxis]
GO:0006954 [inflammatory response]
GO:0006955 [immune response]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0009897 [external side of plasma membrane]
GO:0016021 [integral component of membrane]
GO:0016493 [C-C chemokine receptor activity]
GO:0048872 [homeostasis of number of cells]
GO:0070098 [chemokine-mediated signaling pathway]
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 360 aa
41.4 kDa 		No 7

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.