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NUDT14

GENERAL INFORMATION

Gene name

 NUDT14

Gene description

 Nudix (nucleoside diphosphate linked moiety X)-type motif 14

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA046755
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and ovarian cancer (favourable).
Renal cancer p<0.001
Ovarian cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA046755

GENE INFORMATION

Gene name

 NUDT14 (HGNC Symbol)

Synonyms

 UGPP

Description

 Nudix (nucleoside diphosphate linked moiety X)-type motif 14 (HGNC Symbol)

Entrez gene summary

 UDP-glucose (UDPG) acts as the sugar donor in numerous glycosylation reactions, including those involved in the production of glycogen. NUDT14 is a UDPG pyrophosphatase (EC 3.6.1.45) that hydrolyzes UDPG to produce glucose 1-phosphate and UMP (Yagi et al., 2003 [PubMed 12429023]).[supplied by OMIM, Mar 2008]

Chromosome

 14

Cytoband

 q32.33

Chromosome location (bp)

 105172938 - 105181323

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000183828 (version 83.38)

Entrez gene

 256281

UniProt

 O95848 (UniProt - Evidence at protein level)

neXtProt

 NX_O95848

Antibodypedia

 NUDT14 antibodies

PROTEIN BROWSER
NUDT14-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NUDT14-001
ENSP00000376349
ENST00000392568
O95848 [Direct mapping]
Uridine diphosphate glucose pyrophosphatase
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Enzymes
   ENZYME proteins
   Hydrolases
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0008152 [metabolic process]
GO:0008768 [UDP-sugar diphosphatase activity]
GO:0016787 [hydrolase activity]
GO:0016818 [hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides]
GO:0046872 [metal ion binding]
GO:0047631 [ADP-ribose diphosphatase activity]
GO:0070062 [extracellular exosome]
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 222 aa
24.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.