Expression of KIRREL in cancer - Summary - The Human Protein Atlas

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KIRREL

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	KIRREL
Gene description	Kin of IRRE like (Drosophila)
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (WM-115)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in glomeruli in kidney.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA030458
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), cervical cancer (unfavourable) and urothelial cancer (unfavourable).
Renal cancer p<0.001 Cervical cancer p<0.001 Urothelial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA030458

GENE INFORMATION
Gene name	KIRREL (HGNC Symbol)
Synonyms	NEPH1
Description	Kin of IRRE like (Drosophila) (HGNC Symbol)
Entrez gene summary	NEPH1 is a member of the nephrin-like protein family, which includes NEPH2 (MIM 607761) and NEPH3 (MIM 607762). The cytoplasmic domains of these proteins interact with the C terminus of podocin (NPHS2; MIM 604766), and the genes are expressed in kidney podocytes, cells involved in ensuring size- and charge-selective ultrafiltration (Sellin et al., 2003 [PubMed 12424224]).[supplied by OMIM, Mar 2008]
Chromosome	1
Cytoband	q23.1
Chromosome location (bp)	157993273 - 158100262
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000183853 (version 83.38)
Entrez gene	55243
UniProt	Q96J84 (UniProt - Evidence at protein level)
neXtProt	NX_Q96J84
Antibodypedia	KIRREL antibodies

PROTEIN BROWSER

KIRREL-001	KIRREL-002	KIRREL-003	KIRREL-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KIRREL-001 ENSP00000352138 ENST00000359209	Q96J84 [Direct mapping] Kin of IRRE-like protein 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001933 [negative regulation of protein phosphorylation] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005911 [cell-cell junction] GO:0007588 [excretion] GO:0016021 [integral component of membrane] GO:0016337 [single organismal cell-cell adhesion] GO:0017022 [myosin binding] GO:0030838 [positive regulation of actin filament polymerization] GO:0031253 [cell projection membrane] GO:0043198 [dendritic shaft] GO:0045121 [membrane raft] GO:0048471 [perinuclear region of cytoplasm] GO:0070062 [extracellular exosome] Show all	757 aa 83.5 kDa	Yes	1
KIRREL-002 ENSP00000353202 ENST00000360089	Q5W0F9 [Direct mapping] Kin of IRRE-like protein 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	593 aa 65.7 kDa	No	1
KIRREL-003 ENSP00000357154 ENST00000368172	Q5W0G0 [Direct mapping] Kin of IRRE-like protein 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	571 aa 63.1 kDa	No	1
KIRREL-201 ENSP00000357155 ENST00000368173	B4DN67 [Direct mapping] Kin of IRRE-like protein 1; cDNA FLJ56360, highly similar to Kin of IRRE-like protein 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	657 aa 72.7 kDa	Yes	1

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.