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Malignant gliomas showed strong nuclear staining while several malignant melanomas, colorectal and thyroid cancers displayed moderate to strong cytoplasmic and/or nuclear positivity. Remaining malignancies were generally weakly stained or negative.
Q86VI3 [Direct mapping] Ras GTPase-activating-like protein IQGAP3
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MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000082 [G1/S transition of mitotic cell cycle] GO:0000187 [activation of MAPK activity] GO:0001934 [positive regulation of protein phosphorylation] GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005911 [cell-cell junction] GO:0007165 [signal transduction] GO:0007264 [small GTPase mediated signal transduction] GO:0007265 [Ras protein signal transduction] GO:0008361 [regulation of cell size] GO:0010628 [positive regulation of gene expression] GO:0010629 [negative regulation of gene expression] GO:0016328 [lateral plasma membrane] GO:0017016 [Ras GTPase binding] GO:0017048 [Rho GTPase binding] GO:0033601 [positive regulation of mammary gland epithelial cell proliferation] GO:0043087 [regulation of GTPase activity] GO:0043547 [positive regulation of GTPase activity] GO:0070371 [ERK1 and ERK2 cascade] GO:0070856 [myosin VI light chain binding] GO:0071310 [cellular response to organic substance]