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Few cases of melanomas, thyroid, lung and endometrial cancers displayed strong cytoplasmic staining. Moderate positivity was observed in several cases of melanomas and ovarian cancers along with few cases of breast, prostate and stomach cancers. Remaining cancer tissues were weakly stained or negative.
GENE INFORMATION
Gene name
TOB2 (HGNC Symbol)
Synonyms
bK223H9, TOB4, TOBL, TROB2
Description
Transducer of ERBB2, 2 (HGNC Symbol)
Entrez gene summary
TOB2 belongs to the TOB (see TOB1; MIM 605523)/BTG1 (MIM 109580) family of antiproliferative proteins, which are involved in the regulation of cell cycle progression.[supplied by OMIM, Apr 2004]