Expression of UTY in cancer - Summary - The Human Protein Atlas

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UTY

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	UTY
Gene description	Ubiquitously transcribed tetratricopeptide repeat containing, Y-linked
Protein class	Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	13
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (HEL)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Mainly a dot like nuclear expression in lymphoid tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene. Presumed off target binding observed and disregarded.
Reliability score	Supported based on 2 antibodies. HPA000568 , HPA001165
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA000568	HPA001165

GENE INFORMATION
Gene name	UTY (HGNC Symbol)
Synonyms	KDM6AL
Description	Ubiquitously transcribed tetratricopeptide repeat containing, Y-linked (HGNC Symbol)
Entrez gene summary	This gene encodes a protein containing tetratricopeptide repeats which are thought to be involved in protein-protein interactions. The encoded protein is also a minor histocompatibility antigen which may induce graft rejection of male stem cell grafts. A large number of alternatively spliced transcripts have been observed for this gene, but the full length nature of some of these variants has not been determined. [provided by RefSeq, Apr 2012]
Chromosome	Y
Cytoband	q11.221
Chromosome location (bp)	13248379 - 13480673
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000183878 (version 83.38)
Entrez gene	7404
UniProt	O14607 (UniProt - Evidence at protein level)
neXtProt	NX_O14607
Antibodypedia	UTY antibodies

PROTEIN BROWSER

UTY-001	UTY-002	UTY-003	UTY-004	UTY-008	UTY-201	UTY-202	UTY-203	UTY-204	UTY-205	UTY-206	UTY-207	UTY-208

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
UTY-001 ENSP00000328939 ENST00000331397	O14607 [Direct mapping] Histone demethylase UTY Show all	THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0010468 [regulation of gene expression] GO:0046872 [metal ion binding] GO:0051213 [dioxygenase activity] GO:0055114 [oxidation-reduction process] GO:0071557 [histone H3-K27 demethylation] GO:0071558 [histone demethylase activity (H3-K27 specific)] Show all	1347 aa 149.5 kDa	No	0
UTY-002 ENSP00000355420 ENST00000362096	O14607 [Direct mapping] Histone demethylase UTY Show all	THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0010468 [regulation of gene expression] GO:0046872 [metal ion binding] GO:0051213 [dioxygenase activity] GO:0055114 [oxidation-reduction process] GO:0071557 [histone H3-K27 demethylation] GO:0071558 [histone demethylase activity (H3-K27 specific)] Show all	1240 aa 137.2 kDa	No	0
UTY-003 ENSP00000330446 ENST00000329134	O14607 [Direct mapping] Histone demethylase UTY Show all	THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0010468 [regulation of gene expression] GO:0046872 [metal ion binding] GO:0051213 [dioxygenase activity] GO:0055114 [oxidation-reduction process] GO:0071557 [histone H3-K27 demethylation] GO:0071558 [histone demethylase activity (H3-K27 specific)] Show all	1079 aa 118.1 kDa	No	0
UTY-004 ENSP00000372349 ENST00000382893	A6NCS7 [Direct mapping] Histone demethylase UTY Show all	THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0010468 [regulation of gene expression] GO:0046872 [metal ion binding] GO:0071557 [histone H3-K27 demethylation] GO:0071558 [histone demethylase activity (H3-K27 specific)] Show all	207 aa 23.5 kDa	No	0
UTY-008 ENSP00000485539 ENST00000624098	O14607 [Direct mapping] Histone demethylase UTY Show all	THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0010468 [regulation of gene expression] GO:0046872 [metal ion binding] GO:0051213 [dioxygenase activity] GO:0055114 [oxidation-reduction process] GO:0071557 [histone H3-K27 demethylation] GO:0071558 [histone demethylase activity (H3-K27 specific)] Show all	1211 aa 134.8 kDa	No	0
UTY-201 ENSP00000372352 ENST00000382896	O14607 [Direct mapping] Histone demethylase UTY Show all	THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0010468 [regulation of gene expression] GO:0046872 [metal ion binding] GO:0051213 [dioxygenase activity] GO:0055114 [oxidation-reduction process] GO:0071557 [histone H3-K27 demethylation] GO:0071558 [histone demethylase activity (H3-K27 specific)] Show all	1392 aa 154.4 kDa	No	0
UTY-202 ENSP00000439922 ENST00000537580	A0A096LPD8 [Direct mapping] Histone demethylase UTY Show all	THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0010468 [regulation of gene expression] GO:0046872 [metal ion binding] GO:0071557 [histone H3-K27 demethylation] GO:0071558 [histone demethylase activity (H3-K27 specific)] Show all	1335 aa 147.7 kDa	No	0
UTY-203 ENSP00000445274 ENST00000538878	F5H3N7 [Direct mapping] Histone demethylase UTY Show all	THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0010468 [regulation of gene expression] GO:0046872 [metal ion binding] GO:0071557 [histone H3-K27 demethylation] GO:0071558 [histone demethylase activity (H3-K27 specific)] Show all	1363 aa 151.3 kDa	No	0
UTY-204 ENSP00000441943 ENST00000540140	F5GWV3 [Direct mapping] Histone demethylase UTY Show all	THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0010468 [regulation of gene expression] GO:0046872 [metal ion binding] GO:0071557 [histone H3-K27 demethylation] GO:0071558 [histone demethylase activity (H3-K27 specific)] Show all	1389 aa 154 kDa	Yes	0
UTY-205 ENSP00000442047 ENST00000545955	F5H8B4 [Direct mapping] Histone demethylase UTY Show all	THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0001701 [in utero embryonic development] GO:0003007 [heart morphogenesis] GO:0003682 [chromatin binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0007507 [heart development] GO:0010468 [regulation of gene expression] GO:0031935 [regulation of chromatin silencing] GO:0043234 [protein complex] GO:0045184 [establishment of protein localization] GO:0046872 [metal ion binding] GO:0048568 [embryonic organ development] GO:0051864 [histone demethylase activity (H3-K36 specific)] GO:0060070 [canonical Wnt signaling pathway] GO:0070544 [histone H3-K36 demethylation] GO:0071557 [histone H3-K27 demethylation] GO:0071558 [histone demethylase activity (H3-K27 specific)] GO:0086003 [cardiac muscle cell contraction] Show all	1444 aa 160.2 kDa	Yes	0
UTY-206 ENSP00000485013 ENST00000612274	A0A087X2I9 [Direct mapping] Histone demethylase UTY Show all	THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0010468 [regulation of gene expression] GO:0046872 [metal ion binding] GO:0071557 [histone H3-K27 demethylation] GO:0071558 [histone demethylase activity (H3-K27 specific)] Show all	1367 aa 151.6 kDa	No	0
UTY-207 ENSP00000483735 ENST00000617789	A0A087X0Y2 [Direct mapping] Histone demethylase UTY Show all	THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0010468 [regulation of gene expression] GO:0046872 [metal ion binding] GO:0071557 [histone H3-K27 demethylation] GO:0071558 [histone demethylase activity (H3-K27 specific)] Show all	1399 aa 155.3 kDa	No	0
UTY-208 ENSP00000484698 ENST00000618474	A0A087X248 [Direct mapping] Histone demethylase UTY Show all	THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0010468 [regulation of gene expression] GO:0046872 [metal ion binding] GO:0071557 [histone H3-K27 demethylation] GO:0071558 [histone demethylase activity (H3-K27 specific)] Show all	1264 aa 139.8 kDa	No	0

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The Human Protein Atlas

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