Cell atlas - DNAH2 - The Human Protein Atlas

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DNAH2

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TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Microtubules

Human cell
	Microtubules

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GENERAL INFORMATION
Gene name	DNAH2
Gene description	Dynein, axonemal, heavy chain 2
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the microtubules.
RNA cell category	Cell line enhanced (CACO-2, SCLC-21H, SiHa, A-431, CAPAN-2)
Protein evidence	Evidence at protein level
Main location	Localized to the Microtubules (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA067103
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (CACO-2, SCLC-21H, SiHa, A-431, CAPAN-2) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the microtubules.

Main location

Microtubules (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA067103	CACO-2	Microtubules
	HPA067103	SiHa	Microtubules
	HPA067103	U-2 OS	Microtubules

GENE INFORMATION
Gene name	DNAH2 (HGNC Symbol)
Synonyms	DNHD3, FLJ46675, KIAA1503
Description	Dynein, axonemal, heavy chain 2 (HGNC Symbol)
Entrez gene summary	Dyneins are microtubule-associated motor protein complexes composed of several heavy, light, and intermediate chains. The axonemal dyneins, found in cilia and flagella, are components of the outer and inner dynein arms attached to the peripheral microtubule doublets. DNAH2 is an axonemal inner arm dynein heavy chain (Chapelin et al., 1997 [PubMed 9256245]).[supplied by OMIM, Mar 2008]
Chromosome	17
Cytoband	p13.1
Chromosome location (bp)	7717354 - 7833744
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000183914 (version 83.38)
Entrez gene	146754
UniProt	Q9P225 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9P225
Antibodypedia	DNAH2 antibodies

PROTEIN BROWSER

DNAH2-001	DNAH2-002	DNAH2-003	DNAH2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DNAH2-001 ENSP00000458355 ENST00000572933	Q9P225 [Direct mapping] Dynein heavy chain 2, axonemal Show all	MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0001539 [cilium or flagellum-dependent cell motility] GO:0003777 [microtubule motor activity] GO:0005524 [ATP binding] GO:0005858 [axonemal dynein complex] GO:0005874 [microtubule] GO:0007018 [microtubule-based movement] GO:0008152 [metabolic process] GO:0016887 [ATPase activity] GO:0030286 [dynein complex] GO:0031512 [motile primary cilium] Show all	4427 aa 507.7 kDa	No	0
DNAH2-002 ENSP00000460245 ENST00000570791	Q9P225 [Direct mapping] Dynein heavy chain 2, axonemal Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0001539 [cilium or flagellum-dependent cell motility] GO:0003777 [microtubule motor activity] GO:0005524 [ATP binding] GO:0005858 [axonemal dynein complex] GO:0005874 [microtubule] GO:0007018 [microtubule-based movement] GO:0008152 [metabolic process] GO:0016887 [ATPase activity] Show all	872 aa 99.9 kDa	No	1
DNAH2-003 ENSP00000461726 ENST00000575105	I3L520 [Direct mapping] Dynein heavy chain 2, axonemal Show all	MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Show all	GO:0003777 [microtubule motor activity] GO:0007018 [microtubule-based movement] GO:0008152 [metabolic process] GO:0030286 [dynein complex] Show all	1159 aa 132.8 kDa	No	0
DNAH2-201 ENSP00000373825 ENST00000389173	Q9P225 [Direct mapping] Dynein heavy chain 2, axonemal Show all	MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Show all	GO:0001539 [cilium or flagellum-dependent cell motility] GO:0003777 [microtubule motor activity] GO:0005524 [ATP binding] GO:0005858 [axonemal dynein complex] GO:0005874 [microtubule] GO:0007018 [microtubule-based movement] GO:0008152 [metabolic process] GO:0016887 [ATPase activity] GO:0030286 [dynein complex] Show all	4427 aa 507.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.