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PRKX

GENERAL INFORMATION

Gene name

 PRKX

Gene description

 Protein kinase, X-linked

Protein class

 Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (thyroid gland)
GTEx:Expressed in all
FANTOM5:Mixed

Protein evidence

 Evidence at protein level

Protein expression

 Nuclear expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA015324
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Bone marrow

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (thyroid gland)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed

GENE INFORMATION

Gene name

 PRKX (HGNC Symbol)

Synonyms

 PKX1

Description

 Protein kinase, X-linked (HGNC Symbol)

Entrez gene summary

 This gene encodes a serine threonine protein kinase that has similarity to the catalytic subunit of cyclic AMP dependent protein kinases. The encoded protein is developmentally regulated and may be involved in renal epithelial morphogenesis. This protein may also be involved in macrophage and granulocyte maturation. Abnormal recombination between this gene and a related pseudogene on chromosome Y is a frequent cause of sex reversal disorder in XX males and XY females. Pseudogenes of this gene are found on chromosomes X, 15 and Y. [provided by RefSeq, Feb 2010]

Chromosome

 X

Cytoband

 p22.33

Chromosome location (bp)

 3604370 - 3713608

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000183943 (version 83.38)

Entrez gene

 5613

UniProt

 P51817 (UniProt - Evidence at protein level)

neXtProt

 NX_P51817

Antibodypedia

 PRKX antibodies

PROTEIN BROWSER
PRKX-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PRKX-001
ENSP00000262848
ENST00000262848
P51817 [Direct mapping]
cAMP-dependent protein kinase catalytic subunit PRKX
A0A024RBU5 [Target identity:100%; Query identity:100%]
Protein kinase, X-linked, isoform CRA_b
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   AGC Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001525 [angiogenesis]
GO:0001935 [endothelial cell proliferation]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004691 [cAMP-dependent protein kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006468 [protein phosphorylation]
GO:0007155 [cell adhesion]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0030099 [myeloid cell differentiation]
GO:0030155 [regulation of cell adhesion]
GO:0030334 [regulation of cell migration]
GO:0031589 [cell-substrate adhesion]
GO:0043542 [endothelial cell migration]
GO:0046777 [protein autophosphorylation]
GO:0060562 [epithelial tube morphogenesis]
GO:0060993 [kidney morphogenesis]
GO:2000696 [regulation of epithelial cell differentiation involved in kidney development]
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 358 aa
40.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.