Expression of SMTN in cancer - Summary - The Human Protein Atlas

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SMTN

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TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	SMTN
Gene description	Smoothelin
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	16
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Highly expressed in cytoplasm of smooth muscle cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 3 antibodies. HPA051778 , HPA058590 , CAB001721
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA051778	HPA058590	CAB001721

GENE INFORMATION
Gene name	SMTN
Synonyms
Description	Smoothelin (HGNC Symbol)
Entrez gene summary	This gene encodes a structural protein that is found exclusively in contractile smooth muscle cells. It associates with stress fibers and constitutes part of the cytoskeleton. This gene is localized to chromosome 22q12.3, distal to the TUPLE1 locus and outside the DiGeorge syndrome deletion. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, May 2011]
Chromosome	22
Cytoband	q12.2
Chromosome location (bp)	31064105 - 31104757
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000183963 (version 83.38)
Entrez gene	6525
UniProt	P53814 (UniProt - Evidence at protein level)
neXtProt	NX_P53814
Antibodypedia	SMTN antibodies

PROTEIN BROWSER

SMTN-001	SMTN-002	SMTN-003	SMTN-009	SMTN-011	SMTN-012	SMTN-013	SMTN-014	SMTN-015	SMTN-017	SMTN-018	SMTN-021	SMTN-023	SMTN-026	SMTN-201	SMTN-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SMTN-001 ENSP00000328635 ENST00000347557	P53814 [Direct mapping] Smoothelin Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003779 [actin binding] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005856 [cytoskeleton] GO:0006939 [smooth muscle contraction] GO:0007517 [muscle organ development] GO:0008307 [structural constituent of muscle] GO:0015629 [actin cytoskeleton] Show all	917 aa 99.1 kDa	No	0
SMTN-002 ENSP00000329532 ENST00000333137	P53814 [Direct mapping] Smoothelin Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003779 [actin binding] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005856 [cytoskeleton] GO:0006939 [smooth muscle contraction] GO:0007517 [muscle organ development] GO:0008307 [structural constituent of muscle] GO:0015629 [actin cytoskeleton] Show all	915 aa 98.9 kDa	No	0
SMTN-003 ENSP00000351593 ENST00000358743	P53814 [Direct mapping] Smoothelin Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003779 [actin binding] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005856 [cytoskeleton] GO:0006939 [smooth muscle contraction] GO:0007517 [muscle organ development] GO:0008307 [structural constituent of muscle] GO:0015629 [actin cytoskeleton] Show all	940 aa 101.8 kDa	No	0
SMTN-009 ENSP00000383919 ENST00000404574	B5MCI0 [Direct mapping] Smoothelin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	438 aa 47.7 kDa	No	0
SMTN-011 ENSP00000398663 ENST00000432777	C9JBH9 [Direct mapping] Smoothelin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		91 aa 9.9 kDa	No	0
SMTN-012 ENSP00000390453 ENST00000422839	C9JGQ0 [Direct mapping] Smoothelin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		37 aa 4.1 kDa	No	0
SMTN-013 ENSP00000401341 ENST00000440425	C9JYU8 [Direct mapping] Smoothelin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005654 [nucleoplasm] GO:0015629 [actin cytoskeleton] Show all	152 aa 17.1 kDa	No	0
SMTN-014 ENSP00000485277 ENST00000482444		Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		5 aa 0.6 kDa	No	0
SMTN-015 ENSP00000399432 ENST00000426927	C9JV14 [Direct mapping] Smoothelin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005654 [nucleoplasm] GO:0015629 [actin cytoskeleton] Show all	141 aa 15.9 kDa	No	0
SMTN-017 ENSP00000394637 ENST00000431481	C9JQZ8 [Direct mapping] Smoothelin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005654 [nucleoplasm] GO:0015629 [actin cytoskeleton] Show all	158 aa 18.3 kDa	No	0
SMTN-018 ENSP00000409990 ENST00000416786	C9JP19 [Direct mapping] Smoothelin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		98 aa 10.9 kDa	No	0
SMTN-021 ENSP00000392329 ENST00000455608	H7BZZ8 [Direct mapping] Smoothelin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		216 aa 23.4 kDa	No	0
SMTN-023 ENSP00000409925 ENST00000438223	H7C372 [Direct mapping] Smoothelin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		127 aa 14.7 kDa	No	0
SMTN-026 ENSP00000485089 ENST00000624247	A0A096LNK9 [Direct mapping] Smoothelin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	311 aa 34.9 kDa	No	0
SMTN-201 ENSP00000479578 ENST00000612341	A0A087WVP4 [Direct mapping] Smoothelin Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	971 aa 104.8 kDa	No	0
SMTN-202 ENSP00000484398 ENST00000619644	A0A087X1R1 [Direct mapping] Smoothelin Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	1002 aa 108 kDa	No	0

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The Human Protein Atlas

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