Expression of NPW in cancer - Summary - The Human Protein Atlas

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NPW

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	NPW
Gene description	Neuropeptide W
Protein class	Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (PC-3, RPMI-8226, SCLC-21H)
HPA (normal tissue):	Tissue enhanced (liver)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and extracellular positivity in anterior pituitary gland.

ANTIBODY IHC RELIABILITY
Data reliability description	Secreted protein, tissue location of RNA and protein might differ and correlation is complex. Presumed off target binding observed and disregarded.
Reliability score	Approved based on 1 antibody. HPA064874
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA064874

GENE INFORMATION
Gene name	NPW (HGNC Symbol)
Synonyms	PPL8
Description	Neuropeptide W (HGNC Symbol)
Entrez gene summary	The product of this gene is processed into 23- and 30-amino acid neuropeptides that bind and activate two G-protein coupled receptors in the central nervous system. The neuropeptides have been shown to enhance cortisol secretion from adrenal cells through the adenylate cyclase/protein kinase A signaling cascade. The preproprotein is translated using a non-AUG initiation codon that is inferred from analyses of the mouse ortholog. [provided by RefSeq, Jul 2008]
Chromosome	16
Cytoband	p13.3
Chromosome location (bp)	2009926 - 2020755
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000183971 (version 83.38)
Entrez gene	283869
UniProt	Q8N729 (UniProt - Evidence at protein level)
neXtProt	NX_Q8N729
Antibodypedia	NPW antibodies

PROTEIN BROWSER

NPW-001	NPW-002	NPW-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NPW-001 ENSP00000456974 ENST00000566435	H3BT17 [Direct mapping] Neuropeptide W Show all	Predicted intracellular proteins Show all	GO:0001664 [G-protein coupled receptor binding] Show all	113 aa 12.4 kDa	No	0
NPW-002 ENSP00000457009 ENST00000567649	H3BT42 [Direct mapping] Neuropeptide W Show all	Predicted intracellular proteins Show all		128 aa 13.9 kDa	No	0
NPW-201 ENSP00000330070 ENST00000329610	Q8N729 [Direct mapping] Neuropeptide W Neuropeptide W-23 Neuropeptide W-30 Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0001664 [G-protein coupled receptor binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007218 [neuropeptide signaling pathway] GO:0007631 [feeding behavior] Show all	165 aa 18 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.