Expression of NPB in cancer - Summary - The Human Protein Atlas

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NPB

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	NPB
Gene description	Neuropeptide B
Protein class	Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Not detected
HPA (cell line):	Cell line enhanced (PC-3, SH-SY5Y, U-2 OS)
HPA (normal tissue):	Tissue enhanced (epididymis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues, mainly in CNS.

ANTIBODY IHC RELIABILITY
Data reliability description	Presumed off target binding observed and disregarded. Pending restaining.
Reliability score	Uncertain based on 1 antibody. HPA057419
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Not detected

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA057419

GENE INFORMATION
Gene name	NPB (HGNC Symbol)
Synonyms	PPL7, PPNPB
Description	Neuropeptide B (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the neuropeptide B/W family of proteins and preproprotein that is proteolytically processed to generate multiple protein products. The encoded products include neuropeptide B-23 and a C-terminally extended form, neuropeptide B-29, which are characterized by an N-terminal brominated tryptophan amino acid. Both of the encoded peptides bind with higher affinity to neuropeptide B/W (NPB/W) receptor 1 compared to the related NPB/W receptor 2. These peptides may regulate feeding, pain perception, and stress in rodents. [provided by RefSeq, Jul 2015]
Chromosome	17
Cytoband	q25.3
Chromosome location (bp)	81900745 - 81902905
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000183979 (version 83.38)
Entrez gene	256933
UniProt	Q8NG41 (UniProt - Evidence at protein level)
neXtProt	NX_Q8NG41
Antibodypedia	NPB antibodies

PROTEIN BROWSER

NPB-001	NPB-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NPB-001 ENSP00000332766 ENST00000333383	Q8NG41 [Direct mapping] Neuropeptide B Neuropeptide B-23 Neuropeptide B-29 Show all	THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0001664 [G-protein coupled receptor binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007218 [neuropeptide signaling pathway] Show all	125 aa 13.1 kDa	Yes	0
NPB-002 ENSP00000461824 ENST00000573081	I3NI19 [Direct mapping] Neuropeptide B Show all	MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0001664 [G-protein coupled receptor binding] Show all	156 aa 16.3 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.